Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 2050478..2051001 Replicon chromosome
Accession NZ_CP017239
Organism Burkholderia cenocepacia strain CR318

Toxin (Protein)


Gene name relE Uniprot ID B1K8I5
Locus tag BHQ31_RS26235 Protein ID WP_012339674.1
Coordinates 2050735..2051001 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1K8I6
Locus tag BHQ31_RS26230 Protein ID WP_011547275.1
Coordinates 2050478..2050738 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHQ31_RS26205 2045849..2047057 - 1209 WP_012339678.1 acetate/propionate family kinase -
BHQ31_RS26210 2047068..2048039 - 972 WP_006480840.1 phosphate acetyltransferase -
BHQ31_RS26215 2048187..2049062 + 876 WP_012339677.1 ATP synthase F1 subunit gamma -
BHQ31_RS26220 2049073..2049531 + 459 WP_023476056.1 ATP synthase F1 subunit epsilon -
BHQ31_RS26225 2049554..2050273 - 720 Protein_1824 GNAT family N-acetyltransferase -
BHQ31_RS26230 2050478..2050738 + 261 WP_011547275.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BHQ31_RS26235 2050735..2051001 + 267 WP_012339674.1 Txe/YoeB family addiction module toxin Toxin
BHQ31_RS26240 2051051..2051674 + 624 WP_006480833.1 HAD hydrolase-like protein -
BHQ31_RS26245 2052080..2052658 + 579 WP_012339672.1 DUF4142 domain-containing protein -
BHQ31_RS26250 2052779..2053378 - 600 WP_012339671.1 GNAT family N-acetyltransferase -
BHQ31_RS26255 2053439..2054353 - 915 WP_011547270.1 LysR family transcriptional regulator -
BHQ31_RS26260 2054462..2055700 + 1239 WP_012339670.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10530.85 Da        Isoelectric Point: 8.0229

>T66281 WP_012339674.1 NZ_CP017239:2050735-2051001 [Burkholderia cenocepacia]
MSVRRVLFTSDAWDDHVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQLSI
VSCRYHYE

Download         Length: 267 bp

>T66281 NZ_CP017239:2050735-2051001 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACCATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAACTCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9745.00 Da        Isoelectric Point: 6.0717

>AT66281 WP_011547275.1 NZ_CP017239:2050478-2050738 [Burkholderia cenocepacia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Download         Length: 261 bp

>AT66281 NZ_CP017239:2050478-2050738 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1K8I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9NJ62

References