Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1847250..1849021 Replicon chromosome
Accession NZ_CP017239
Organism Burkholderia cenocepacia strain CR318

Toxin (Protein)


Gene name doc Uniprot ID B1K293
Locus tag BHQ31_RS25295 Protein ID WP_011547425.1
Coordinates 1848104..1849021 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1K294
Locus tag BHQ31_RS25290 Protein ID WP_011547426.1
Coordinates 1847250..1848107 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHQ31_RS25270 1842413..1843903 - 1491 WP_012339775.1 aldehyde dehydrogenase -
BHQ31_RS25275 1843976..1844803 - 828 WP_011547429.1 aspartate dehydrogenase -
BHQ31_RS25280 1844796..1846463 - 1668 WP_012339774.1 thiamine pyrophosphate-binding protein -
BHQ31_RS25285 1846456..1847253 - 798 WP_011547427.1 SDR family oxidoreductase -
BHQ31_RS25290 1847250..1848107 - 858 WP_011547426.1 IclR family transcriptional regulator Antitoxin
BHQ31_RS25295 1848104..1849021 - 918 WP_011547425.1 alpha/beta hydrolase Toxin
BHQ31_RS25300 1849040..1849567 - 528 WP_011547424.1 cupin domain-containing protein -
BHQ31_RS25305 1849602..1850372 - 771 WP_011547423.1 SDR family oxidoreductase -
BHQ31_RS25310 1850365..1851435 - 1071 WP_012339773.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BHQ31_RS25315 1851496..1851807 - 312 WP_006478722.1 hypothetical protein -
BHQ31_RS25320 1851809..1852126 - 318 WP_006478721.1 non-heme iron oxygenase ferredoxin subunit -
BHQ31_RS25325 1852571..1853650 + 1080 WP_012339772.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(58-286)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 31280.60 Da        Isoelectric Point: 7.7325

>T66280 WP_011547425.1 NZ_CP017239:c1849021-1848104 [Burkholderia cenocepacia]
MSVIDKRERERDRTAAFAALLGQFPEQRCAAGAAGAIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGA
SRRVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLVRVMPARIAGLLLISPAGGYG
SAPAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRG
RTAVAVGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDPQRGPA

Download         Length: 918 bp

>T66280 NZ_CP017239:c1849021-1848104 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGCGAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCA
GCGTTGCGCGGCCGGCGCGGCGGGCGCGATCGGCTACCGTGAGGCGGGTGCAGGCGAGGCCGGCGCGCAGCATGCGGGCC
GTGCGCTGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTGGGTGCA
TCGCGGCGCGTACTCGCGTGGGATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGA
TTACGCGGCATCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGA
TCATCGCGGGCGGCCTCGTCCGCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGC
AGCGCACCGGCCGAGACCCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGC
CGAGCAGCGCAGCGGCAACATGCTGTCCGGTTTCGCGAACGAGGAGGCAAAGGCATGGGTGCGCTGGAACATGGCGCGCA
TCGTGCCGGCCGGCTACGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGC
CGCACGGCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGT
CGGGCTGCAGGTGATTCCGCAGGCGGGGCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCGCTGATCGACACGT
TCTGTCGTCAGTGCGACCCACAGCGGGGGCCGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31315.76 Da        Isoelectric Point: 6.5054

>AT66280 WP_011547426.1 NZ_CP017239:c1848107-1847250 [Burkholderia cenocepacia]
MSEPLQQNESDNAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT66280 NZ_CP017239:c1848107-1847250 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAACAAAACGAATCCGACAACGCGAAGGCCGAAGCCAGCTACGTCGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAACGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGTTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTTGACGCGCTGTACGACGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1K293

Antitoxin

Source ID Structure
AlphaFold DB B1K294

References