Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1573562..1574201 Replicon chromosome
Accession NZ_CP017239
Organism Burkholderia cenocepacia strain CR318

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N9F707
Locus tag BHQ31_RS24065 Protein ID WP_011547639.1
Coordinates 1573562..1573972 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1K469
Locus tag BHQ31_RS24070 Protein ID WP_011547638.1
Coordinates 1573965..1574201 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHQ31_RS24025 1568944..1569243 - 300 WP_011547642.1 hypothetical protein -
BHQ31_RS24030 1569455..1569703 - 249 WP_006478971.1 hypothetical protein -
BHQ31_RS24035 1570153..1570401 - 249 WP_011547641.1 hypothetical protein -
BHQ31_RS24040 1570398..1571645 - 1248 WP_011547640.1 alkaline phosphatase family protein -
BHQ31_RS24050 1572215..1572478 - 264 WP_006483034.1 translation initiation factor IF-1 -
BHQ31_RS24060 1572945..1573148 - 204 WP_006483056.1 cold-shock protein -
BHQ31_RS24065 1573562..1573972 - 411 WP_011547639.1 type II toxin-antitoxin system VapC family toxin Toxin
BHQ31_RS24070 1573965..1574201 - 237 WP_011547638.1 DNA-binding protein Antitoxin
BHQ31_RS24075 1574692..1575918 + 1227 WP_012339914.1 acyltransferase -
BHQ31_RS24080 1575938..1576615 - 678 WP_012339913.1 hypothetical protein -
BHQ31_RS36070 1576974..1577195 + 222 WP_027811879.1 hypothetical protein -
BHQ31_RS24090 1577765..1578454 + 690 WP_171984323.1 hypothetical protein -
BHQ31_RS36075 1578564..1578884 - 321 WP_166488159.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1570153..1578454 8301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15202.37 Da        Isoelectric Point: 6.8816

>T66279 WP_011547639.1 NZ_CP017239:c1573972-1573562 [Burkholderia cenocepacia]
MIDTNVISEIRKGRRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWIAMILSGYAPNILP
VDIETSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 411 bp

>T66279 NZ_CP017239:c1573972-1573562 [Burkholderia cenocepacia]
TTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAGGCGAACCAATCGCGGCGTGCGGGCGTTCTTCAGGCAGGC
CGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGTTGCGGCGCGGCGTCGACCTGATCCGTCATC
GCGGCGATCATAGCCAGGCGTCGGCGCTCGAGGCCTGGATCGCGATGATCCTGTCGGGCTATGCGCCGAACATCCTGCCG
GTCGATATCGAGACCAGCCAGATGTGGGGGCATTTGCGGGTGCCCGATCCGACGCACGAACTCGACAAGCTGATCGCGGC
CACCGCGCTGATCAACGATCTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACTGGCGTCCGGTTGCTGAATC
CGTTCGACTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8692.75 Da        Isoelectric Point: 5.0916

>AT66279 WP_011547638.1 NZ_CP017239:c1574201-1573965 [Burkholderia cenocepacia]
MANLLVRNVDDTIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLLSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT66279 NZ_CP017239:c1574201-1573965 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTATCGTTCAAAGCCTGCGTGAGCAGGCGGCGGCCAATGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGGACATTTGCTCAAGTGCTGCTGA
GCATGCCGGAGGTGGGCGAGGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N9F707

Antitoxin

Source ID Structure
AlphaFold DB B1K469

References