Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2829327..2829950 Replicon chromosome
Accession NZ_CP017236
Organism Yersinia ruckeri strain QMA0440 isolate 14/0165-5k

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag QMA0440_RS13330 Protein ID WP_038243726.1
Coordinates 2829747..2829950 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag QMA0440_RS13325 Protein ID WP_004718732.1
Coordinates 2829327..2829695 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMA0440_RS13310 2827581..2827835 + 255 WP_038243728.1 type B 50S ribosomal protein L31 -
QMA0440_RS13315 2827855..2827998 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
QMA0440_RS18250 2828117..2828278 - 162 WP_004718735.1 hypothetical protein -
QMA0440_RS13325 2829327..2829695 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
QMA0440_RS13330 2829747..2829950 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
QMA0440_RS13340 2830759..2831073 + 315 WP_004718728.1 MGMT family protein -
QMA0440_RS13345 2831452..2832315 + 864 WP_004718726.1 acyl-CoA thioesterase II -
QMA0440_RS13350 2832430..2833719 - 1290 WP_004718723.1 ammonium transporter AmtB -
QMA0440_RS13355 2833758..2834096 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T66272 WP_038243726.1 NZ_CP017236:2829747-2829950 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T66272 NZ_CP017236:2829747-2829950 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT66272 WP_004718732.1 NZ_CP017236:2829327-2829695 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT66272 NZ_CP017236:2829327-2829695 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References