Detailed information of TA system TA066271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1772500..1773418
• Replicon: chromosome
• Accession: NZ_CP017236
• Organism: Yersinia ruckeri strain QMA0440 isolate 14/0165-5k

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QMA0440_RS08265
• Protein ID: WP_038242633.1
• Coordinates: 1772500..1772958 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: QMA0440_RS08270
• Protein ID: WP_038242631.1
• Coordinates: 1772972..1773418 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMA0440_RS08235	1768422..1769087	+	666	WP_004717561.1	phage shock protein PspA	-
QMA0440_RS08240	1769171..1769398	+	228	WP_038242637.1	envelope stress response membrane protein PspB	-
QMA0440_RS08245	1769398..1769757	+	360	WP_004717559.1	envelope stress response membrane protein PspC	-
QMA0440_RS08250	1769821..1770063	+	243	WP_087931058.1	phage shock protein PspD	-
QMA0440_RS08255	1770044..1771441	+	1398	WP_004717556.1	YcjX family protein	-
QMA0440_RS08260	1771438..1772496	+	1059	WP_038242635.1	YcjF family protein	-
QMA0440_RS08265	1772500..1772958	-	459	WP_038242633.1	RES domain-containing protein	Toxin
QMA0440_RS08270	1772972..1773418	-	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
QMA0440_RS08275	1773736..1775343	+	1608	WP_038242630.1	transcriptional regulator TyrR	-
QMA0440_RS08280	1775378..1775881	-	504	WP_004717547.1	thiol peroxidase	-
QMA0440_RS08285	1776031..1777005	+	975	WP_038242629.1	L-Ala-D/L-Glu epimerase	-
QMA0440_RS08290	1777016..1777720	-	705	WP_004717543.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T66271 WP_038242633.1 NZ_CP017236:c1772958-1772500 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T66271 NZ_CP017236:c1772958-1772500 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT66271 WP_038242631.1 NZ_CP017236:c1773418-1772972 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT66271 NZ_CP017236:c1773418-1772972 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3