Detailed information of TA system TA066262

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 686406..687075
• Replicon: chromosome
• Accession: NZ_CP017236
• Organism: Yersinia ruckeri strain QMA0440 isolate 14/0165-5k

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: QMA0440_RS03035
• Protein ID: WP_038241020.1
• Coordinates: 686653..687075 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: QMA0440_RS03030
• Protein ID: WP_004719196.1
• Coordinates: 686406..686672 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMA0440_RS03015	683659..683999	-	341	Protein_571	HD domain-containing protein	-
QMA0440_RS03020	684307..684981	+	675	WP_049687854.1	hemolysin III family protein	-
QMA0440_RS03025	685120..686112	-	993	WP_038241018.1	tRNA-modifying protein YgfZ	-
QMA0440_RS03030	686406..686672	+	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
QMA0440_RS03035	686653..687075	+	423	WP_038241020.1	protein YgfX	Toxin
QMA0440_RS03040	687223..687741	-	519	WP_038241022.1	flavodoxin FldB	-
QMA0440_RS03045	687849..688748	+	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
QMA0440_RS03050	688780..689496	+	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QMA0440_RS03055	689503..691236	+	1734	WP_038241024.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T66262 WP_038241020.1 NZ_CP017236:686653-687075 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T66262 NZ_CP017236:686653-687075 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT66262 WP_004719196.1 NZ_CP017236:686406-686672 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT66262 NZ_CP017236:686406-686672 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A380QS17