Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 52537..53062 Replicon plasmid pFORC51
Accession NZ_CP017233
Organism Salmonella enterica strain FORC_051

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag FORC51_RS24215 Protein ID WP_001159863.1
Coordinates 52757..53062 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag FORC51_RS24210 Protein ID WP_000813641.1
Coordinates 52537..52755 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC51_RS24180 48151..48537 + 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -
FORC51_RS24185 48590..48751 + 162 WP_015059604.1 hypothetical protein -
FORC51_RS24190 49078..50067 - 990 WP_000461382.1 RepB family plasmid replication initiator protein -
FORC51_RS24195 50561..50856 - 296 Protein_65 cytoplasmic protein -
FORC51_RS24200 50976..51206 + 231 WP_001057493.1 hypothetical protein -
FORC51_RS24205 51340..51861 - 522 WP_077681952.1 hypothetical protein -
FORC51_RS24210 52537..52755 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FORC51_RS24215 52757..53062 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
FORC51_RS24220 53064..53354 + 291 WP_001266176.1 hypothetical protein -
FORC51_RS24225 53351..53872 + 522 WP_000198608.1 hypothetical protein -
FORC51_RS24230 53907..54689 + 783 WP_000082169.1 site-specific integrase -
FORC51_RS24235 54698..55411 + 714 WP_000545756.1 EAL domain-containing protein -
FORC51_RS24240 55415..55924 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
FORC51_RS24245 55918..56403 + 486 WP_000905606.1 membrane protein -
FORC51_RS24250 56680..56967 - 288 WP_071530243.1 hypothetical protein -
FORC51_RS24255 57123..57683 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..96999 96999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T66259 WP_001159863.1 NZ_CP017233:52757-53062 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T66259 NZ_CP017233:52757-53062 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT66259 WP_000813641.1 NZ_CP017233:52537-52755 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT66259 NZ_CP017233:52537-52755 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References