Detailed information of TA system TA066210

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3685372..3686029
• Replicon: chromosome
• Accession: NZ_CP017186
• Organism: Enterobacter hormaechei subsp. hoffmannii strain DSM 14563

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A0A6GSQ9
• Locus tag: BFV65_RS17315
• Protein ID: WP_022649305.1
• Coordinates: 3685372..3685782 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: BFV65_RS17320
• Protein ID: WP_069596931.1
• Coordinates: 3685763..3686029 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFV65_RS17295	3681370..3683103	-	1734	WP_022649303.1	single-stranded-DNA-specific exonuclease RecJ	-
BFV65_RS17300	3683109..3683822	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
BFV65_RS17305	3683851..3684747	-	897	WP_048965619.1	site-specific tyrosine recombinase XerD	-
BFV65_RS17310	3684849..3685370	+	522	WP_015571793.1	flavodoxin FldB	-
BFV65_RS17315	3685372..3685782	-	411	WP_022649305.1	protein YgfX	Toxin
BFV65_RS17320	3685763..3686029	-	267	WP_069596931.1	FAD assembly factor SdhE	Antitoxin
BFV65_RS17325	3686324..3687304	+	981	WP_032626101.1	tRNA-modifying protein YgfZ	-
BFV65_RS17330	3687826..3688485	-	660	WP_022649307.1	hemolysin III family protein	-
BFV65_RS17340	3688752..3689483	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16321.21 Da
• Isoelectric Point: 11.4775

>T66210 WP_022649305.1 NZ_CP017186:c3685782-3685372 [Enterobacter hormaechei subsp. hoffmannii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T66210 NZ_CP017186:c3685782-3685372 [Enterobacter hormaechei subsp. hoffmannii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGGGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10508.93 Da
• Isoelectric Point: 4.8310

>AT66210 WP_069596931.1 NZ_CP017186:c3686029-3685763 [Enterobacter hormaechei subsp. hoffmannii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRIVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT66210 NZ_CP017186:c3686029-3685763 [Enterobacter hormaechei subsp. hoffmannii]
ATGGACATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATAGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0A6GSQ9