Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3861282..3861939 Replicon chromosome
Accession NZ_CP017184
Organism Enterobacter roggenkampii strain DSM 16690

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag BFV67_RS18020 Protein ID WP_021242050.1
Coordinates 3861282..3861692 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag BFV67_RS18025 Protein ID WP_006178375.1
Coordinates 3861673..3861939 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV67_RS18000 3857275..3859008 - 1734 WP_069598757.1 single-stranded-DNA-specific exonuclease RecJ -
BFV67_RS18005 3859014..3859727 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BFV67_RS18010 3859756..3860652 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
BFV67_RS18015 3860754..3861275 + 522 WP_069598758.1 flavodoxin FldB -
BFV67_RS18020 3861282..3861692 - 411 WP_021242050.1 protein YgfX Toxin
BFV67_RS18025 3861673..3861939 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
BFV67_RS18030 3862234..3863214 + 981 WP_045351721.1 tRNA-modifying protein YgfZ -
BFV67_RS18035 3863299..3863958 - 660 WP_021242052.1 hemolysin III family protein -
BFV67_RS18045 3864224..3864955 + 732 WP_008499714.1 MurR/RpiR family transcriptional regulator -
BFV67_RS18050 3865072..3866505 + 1434 WP_069598759.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T66196 WP_021242050.1 NZ_CP017184:c3861692-3861282 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T66196 NZ_CP017184:c3861692-3861282 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTATTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT66196 WP_006178375.1 NZ_CP017184:c3861939-3861673 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT66196 NZ_CP017184:c3861939-3861673 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References