Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1056793..1057413 Replicon chromosome
Accession NZ_CP017184
Organism Enterobacter roggenkampii strain DSM 16690

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag BFV67_RS04875 Protein ID WP_008499287.1
Coordinates 1056793..1057011 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag BFV67_RS04880 Protein ID WP_008499288.1
Coordinates 1057039..1057413 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV67_RS04845 1052806..1053066 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
BFV67_RS04850 1053069..1053209 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
BFV67_RS04855 1053206..1053916 - 711 WP_045352701.1 GNAT family N-acetyltransferase -
BFV67_RS04860 1054018..1055478 + 1461 WP_063453152.1 PLP-dependent aminotransferase family protein -
BFV67_RS04865 1055450..1055917 - 468 WP_008499285.1 membrane protein -
BFV67_RS04870 1056035..1056586 - 552 WP_069597935.1 maltose O-acetyltransferase -
BFV67_RS04875 1056793..1057011 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
BFV67_RS04880 1057039..1057413 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
BFV67_RS04885 1057923..1061069 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
BFV67_RS04890 1061092..1062285 - 1194 WP_008499290.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T66186 WP_008499287.1 NZ_CP017184:c1057011-1056793 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T66186 NZ_CP017184:c1057011-1056793 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT66186 WP_008499288.1 NZ_CP017184:c1057413-1057039 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT66186 NZ_CP017184:c1057413-1057039 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References