Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4129413..4130152 Replicon chromosome
Accession NZ_CP017181
Organism Enterobacter kobei strain DSM 13645

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag BFV64_RS19960 Protein ID WP_013087269.1
Coordinates 4129667..4130152 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag BFV64_RS19955 Protein ID WP_007869691.1
Coordinates 4129413..4129679 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV64_RS19930 4124859..4125629 + 771 WP_032638097.1 conjugal transfer protein TraX -
BFV64_RS19935 4125760..4126086 + 327 WP_032638096.1 hypothetical protein -
BFV64_RS19940 4126061..4126867 - 807 WP_032638095.1 DUF4225 domain-containing protein -
BFV64_RS19945 4127747..4128760 - 1014 WP_069602377.1 replication initiation protein -
BFV64_RS19955 4129413..4129679 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
BFV64_RS19960 4129667..4130152 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
BFV64_RS19965 4130397..4131094 - 698 Protein_3922 IS1 family transposase -
BFV64_RS25105 4131150..4131920 - 771 Protein_3923 transposase -
BFV64_RS19985 4131986..4132153 + 168 Protein_3924 family 1 glycosylhydrolase -
BFV64_RS19990 4132232..4133218 - 987 WP_069602379.1 helix-turn-helix domain-containing protein -
BFV64_RS19995 4133344..4133649 + 306 WP_023328886.1 hypothetical protein -
BFV64_RS20000 4133689..4134669 + 981 WP_069602380.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4118042..4149459 31417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T66168 WP_013087269.1 NZ_CP017181:4129667-4130152 [Enterobacter kobei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T66168 NZ_CP017181:4129667-4130152 [Enterobacter kobei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT66168 WP_007869691.1 NZ_CP017181:4129413-4129679 [Enterobacter kobei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT66168 NZ_CP017181:4129413-4129679 [Enterobacter kobei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References