Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3927029..3927686 Replicon chromosome
Accession NZ_CP017181
Organism Enterobacter kobei strain DSM 13645

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag BFV64_RS19000 Protein ID WP_014885136.1
Coordinates 3927029..3927439 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag BFV64_RS19005 Protein ID WP_010435322.1
Coordinates 3927420..3927686 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV64_RS18980 3923023..3924756 - 1734 WP_032635612.1 single-stranded-DNA-specific exonuclease RecJ -
BFV64_RS18985 3924762..3925475 - 714 WP_045134112.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BFV64_RS18990 3925504..3926400 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
BFV64_RS18995 3926502..3927023 + 522 WP_014885135.1 flavodoxin FldB -
BFV64_RS19000 3927029..3927439 - 411 WP_014885136.1 protein YgfX Toxin
BFV64_RS19005 3927420..3927686 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
BFV64_RS19010 3927981..3928961 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
BFV64_RS19015 3929046..3929705 - 660 WP_023331242.1 hemolysin III family protein -
BFV64_RS19020 3929971..3930702 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
BFV64_RS19025 3930819..3932252 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T66167 WP_014885136.1 NZ_CP017181:c3927439-3927029 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T66167 NZ_CP017181:c3927439-3927029 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTATTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT66167 WP_010435322.1 NZ_CP017181:c3927686-3927420 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT66167 NZ_CP017181:c3927686-3927420 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References