Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3765281..3765938 Replicon chromosome
Accession NZ_CP017180
Organism Enterobacter hormaechei subsp. oharae strain DSM 16687

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag BFV66_RS18055 Protein ID WP_017382887.1
Coordinates 3765281..3765691 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag BFV66_RS18060 Protein ID WP_003863437.1
Coordinates 3765672..3765938 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV66_RS18035 3761279..3763012 - 1734 WP_047050807.1 single-stranded-DNA-specific exonuclease RecJ -
BFV66_RS18040 3763018..3763731 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BFV66_RS18045 3763760..3764656 - 897 WP_047050805.1 site-specific tyrosine recombinase XerD -
BFV66_RS18050 3764758..3765279 + 522 WP_015571793.1 flavodoxin FldB -
BFV66_RS18055 3765281..3765691 - 411 WP_017382887.1 protein YgfX Toxin
BFV66_RS18060 3765672..3765938 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
BFV66_RS18065 3766233..3767213 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
BFV66_RS18070 3767325..3767984 - 660 WP_047050804.1 hemolysin III family protein -
BFV66_RS18075 3768251..3768982 + 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
BFV66_RS18080 3769099..3770532 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T66151 WP_017382887.1 NZ_CP017180:c3765691-3765281 [Enterobacter hormaechei subsp. oharae]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T66151 NZ_CP017180:c3765691-3765281 [Enterobacter hormaechei subsp. oharae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT66151 WP_003863437.1 NZ_CP017180:c3765938-3765672 [Enterobacter hormaechei subsp. oharae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT66151 NZ_CP017180:c3765938-3765672 [Enterobacter hormaechei subsp. oharae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References