Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 2409063..2410846 Replicon chromosome
Accession NZ_CP017180
Organism Enterobacter hormaechei subsp. oharae strain DSM 16687

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BFV66_RS11655 Protein ID WP_047053382.1
Coordinates 2409497..2410846 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BFV66_RS11650 Protein ID WP_047053381.1
Coordinates 2409063..2409500 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV66_RS11630 2404082..2405104 + 1023 WP_047053378.1 HTH-type transcriptional regulator GalS -
BFV66_RS11635 2405400..2406398 + 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
BFV66_RS11640 2406478..2407998 + 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
BFV66_RS11645 2408014..2409024 + 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
BFV66_RS11650 2409063..2409500 - 438 WP_047053381.1 helix-turn-helix domain-containing protein Antitoxin
BFV66_RS11655 2409497..2410846 - 1350 WP_047053382.1 type II toxin-antitoxin system HipA family toxin Toxin
BFV66_RS11660 2410981..2411691 - 711 WP_003859314.1 outer membrane permeability protein SanA -
BFV66_RS11665 2411819..2412703 - 885 WP_047053384.1 cytidine deaminase -
BFV66_RS11670 2412832..2413527 - 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
BFV66_RS11675 2413524..2413919 - 396 WP_023295055.1 CidA/LrgA family protein -
BFV66_RS11680 2414088..2415023 + 936 WP_069597669.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-129)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51132.76 Da        Isoelectric Point: 4.6556

>T66142 WP_047053382.1 NZ_CP017180:c2410846-2409497 [Enterobacter hormaechei subsp. oharae]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Download         Length: 1350 bp

>T66142 NZ_CP017180:c2410846-2409497 [Enterobacter hormaechei subsp. oharae]
ATGGAGACGTTAACCGTACAGGCATATCTGAACGAAACATGGACGGATATCGCTCTCATCAAATATCCAGGAAGTGAAAA
AAATGACTGGAATACCACGCAGTTAGACTATCTCACTGAGTATGCGATTAATTTTCTCGACTATGATGATTTTCACGCAG
TCTCAGTCAATCACCCTGTATCACTCTTTTTTGATGACCATGGCCAACCGGGCTGGCTGCGATTTATCGACGATATTATT
CCCGCCGGAGCAAGCCGCCGTTACTGGATTAATGCGCTCGACATCAGTGAATTACCCGTTGGCCAGCAAAATTTCTTATT
GCTGAAATTTGGCACAATGTCCCCTGTGGGGAATTTGCGCATAAAAGAATCCGTCCCAGAATGGAATAAATTCGCCAGCA
CTAAAACGTTTACGGTTGCGGACGTCATCGATCGTGCGGCCGATTTTCTGGATTATGCCCAGGAAAGAGGCGCGGCGGCG
GGTGGTGCAACCGGTGCTGGCGGTGAAGCGCCTAAACTTTTGCTGCGCTGTAGTGAAACTGATGCCATCTGGATCGATAC
CTGGCAAAACGAGCCGGATAACCGGGACCGCTATTATTTGGTTAAATATCCACGCGGTAACAGGACAGAAGTTGATTGTA
ATATTCTGCGAGCTGAATTCCATTATTATCATGAGCTTAACGCGATGGGTTTTTCCACGATCCCAGTGGAAACAATGCGC
CTTGAAGAAGGTAGCCATTACCCGTCTCTGTGGTTACCGCGTTTCGACATAGTGAGAAATGAGCAGGACCAACTGGTCAG
GCTGGGTATGGAATCGGTGTATTCGCTATTACAAAAGGCACCCGGCACCCTCCTTGATCATGAGACAACGTTGCGCGCGT
TAATTAATAAAATCACCTCCAGCCATATGGTCCAGCAGCAGGGCTATCATTTTGATATTCCGGGATTTGTAACAGAATGG
GTGCGTCGCGATCTGCTAAATATTATTTTTGGAAATAGTGACAACCATGGGCGAAATACCGCCTTTGTGAAGGCTGAAAA
TCAAATTATGCTCTCCCCTGTATATGACTTTGCGCCGATGAAAGCCGATCCTGAAGGGATACCAAGAACCCTGAAGTGGT
CATTAACTTGCGAATCAGGGGGGGATTATAATTTCAACACTATCGCACAAACGCTGGCGGAGTGGATCCCTCCCGCAACA
TTACTTGATGCTCTGCATGAAACAGCCGTTCAGCTTATTGATCTCCCGGAAAGGCTGGCGGCGCGAGGCGTTCCGGAACA
GATAATGGAAATGCCCGCGATGGGTTTTCACTATATTCCGGATAAACTATCCCGTTGGGGTTTATTATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16161.57 Da        Isoelectric Point: 10.5154

>AT66142 WP_047053381.1 NZ_CP017180:c2409500-2409063 [Enterobacter hormaechei subsp. oharae]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT66142 NZ_CP017180:c2409500-2409063 [Enterobacter hormaechei subsp. oharae]
ATGAAAACATCTAATGAAGCTGAATCAGAGCTTTTACAGACATTAGCTCAAGTACGCAGCGTAAATAAAAAGCGACATCA
TGACGAGGCGGAAGATCCGGACAAGCCATCGGTAGTGAAGAGGCAACGCGTTTCACAAGGCTTAACGCGGATTAGTACTC
TCGATCGCCAGGCTGTACTGCATGCAGCCATACGGGACATTTTGCTGGGGAAAATTACACAGGGAGAGGCGCTGAAAAGG
CTCAGGGTCGAGGTGTTAGGGCTGAAGCAGGATGAATATGCAAAGCTGGTCAGCGTATCCCGGAAAACATTGTCGGATGT
AGAAAATAACAGAGGCAATTATTCCGCTGACATTATAAATAAAATCTTTAAACCCTTTGGGCTTCAAACCGGACTAGTGC
CCGTTTCAAAATCGCTTATCGCTTCACTTTTCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References