Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1081910..1082530 Replicon chromosome
Accession NZ_CP017180
Organism Enterobacter hormaechei subsp. oharae strain DSM 16687

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag BFV66_RS05145 Protein ID WP_015571250.1
Coordinates 1081910..1082128 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag BFV66_RS05150 Protein ID WP_006809850.1
Coordinates 1082156..1082530 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV66_RS05115 1077922..1078182 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
BFV66_RS05120 1078185..1078325 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
BFV66_RS05125 1078322..1079032 - 711 WP_047051118.1 GNAT family N-acetyltransferase -
BFV66_RS05130 1079134..1080594 + 1461 WP_047051117.1 PLP-dependent aminotransferase family protein -
BFV66_RS05135 1080566..1081033 - 468 WP_017383209.1 membrane protein -
BFV66_RS05140 1081150..1081701 - 552 WP_017694396.1 maltose O-acetyltransferase -
BFV66_RS05145 1081910..1082128 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
BFV66_RS05150 1082156..1082530 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
BFV66_RS05155 1083040..1086186 - 3147 WP_047051116.1 multidrug efflux RND transporter permease subunit AcrB -
BFV66_RS05160 1086209..1087402 - 1194 WP_047051115.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T66139 WP_015571250.1 NZ_CP017180:c1082128-1081910 [Enterobacter hormaechei subsp. oharae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T66139 NZ_CP017180:c1082128-1081910 [Enterobacter hormaechei subsp. oharae]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
AATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTTTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT66139 WP_006809850.1 NZ_CP017180:c1082530-1082156 [Enterobacter hormaechei subsp. oharae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT66139 NZ_CP017180:c1082530-1082156 [Enterobacter hormaechei subsp. oharae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References