Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3869796..3870453 Replicon chromosome
Accession NZ_CP017179
Organism Enterobacter hormaechei subsp. steigerwaltii strain DSM 16691

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag BFV68_RS18265 Protein ID WP_017382887.1
Coordinates 3869796..3870206 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag BFV68_RS18270 Protein ID WP_003863437.1
Coordinates 3870187..3870453 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV68_RS18245 3865794..3867527 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
BFV68_RS18250 3867533..3868246 - 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BFV68_RS18255 3868275..3869171 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
BFV68_RS18260 3869273..3869794 + 522 WP_069596003.1 flavodoxin FldB -
BFV68_RS18265 3869796..3870206 - 411 WP_017382887.1 protein YgfX Toxin
BFV68_RS18270 3870187..3870453 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
BFV68_RS18275 3870748..3871728 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
BFV68_RS18280 3871840..3872499 - 660 WP_003863433.1 hemolysin III family protein -
BFV68_RS18285 3872766..3873497 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
BFV68_RS18290 3873614..3875047 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T66130 WP_017382887.1 NZ_CP017179:c3870206-3869796 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T66130 NZ_CP017179:c3870206-3869796 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGGGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT66130 WP_003863437.1 NZ_CP017179:c3870453-3870187 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT66130 NZ_CP017179:c3870453-3870187 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References