Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 13509..14034 Replicon plasmid unnamed1
Accession NZ_CP017178
Organism Salmonella enterica strain FORC_056

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag FORC56_RS23955 Protein ID WP_001159863.1
Coordinates 13509..13814 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag FORC56_RS23960 Protein ID WP_000813641.1
Coordinates 13816..14034 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC56_RS23915 8888..9448 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
FORC56_RS24555 9604..9891 + 288 WP_071530243.1 hypothetical protein -
FORC56_RS23925 10168..10653 - 486 WP_000905606.1 membrane protein -
FORC56_RS23930 10647..11156 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
FORC56_RS23935 11160..11873 - 714 WP_000545756.1 EAL domain-containing protein -
FORC56_RS23940 11882..12664 - 783 WP_000082169.1 site-specific integrase -
FORC56_RS23945 12699..13220 - 522 WP_000198608.1 hypothetical protein -
FORC56_RS23950 13217..13507 - 291 WP_001266176.1 hypothetical protein -
FORC56_RS23955 13509..13814 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
FORC56_RS23960 13816..14034 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FORC56_RS23965 14710..15231 + 522 WP_077681952.1 hypothetical protein -
FORC56_RS24560 15275..15703 - 429 Protein_21 hypothetical protein -
FORC56_RS23975 15715..16010 + 296 Protein_22 cytoplasmic protein -
FORC56_RS23980 16504..17493 + 990 WP_000461382.1 RepB family plasmid replication initiator protein -
FORC56_RS23985 17820..17981 - 162 WP_015059604.1 hypothetical protein -
FORC56_RS23990 18034..18420 - 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59371 59371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T66114 WP_001159863.1 NZ_CP017178:c13814-13509 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T66114 NZ_CP017178:c13814-13509 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT66114 WP_000813641.1 NZ_CP017178:c14034-13816 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT66114 NZ_CP017178:c14034-13816 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References