Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 118376..119031 Replicon chromosome
Accession NZ_CP017175
Organism Burkholderia mallei strain Bahrain1

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BHL98_RS00510 Protein ID WP_004199884.1
Coordinates 118735..119031 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BHL98_RS00505 Protein ID WP_004202809.1
Coordinates 118376..118732 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHL98_RS00475 114508..115266 + 759 WP_004199892.1 cytochrome c1 -
BHL98_RS00480 115359..115970 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BHL98_RS00485 116040..116561 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BHL98_RS00495 116783..117280 + 498 WP_004199888.1 terminase -
BHL98_RS00500 117277..118332 + 1056 WP_004199886.1 phage portal protein -
BHL98_RS00505 118376..118732 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BHL98_RS00510 118735..119031 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHL98_RS00520 119839..120959 + 1121 WP_038802950.1 IS3 family transposase -
BHL98_RS00525 121007..121558 + 552 Protein_103 flagellar type III secretion system pore protein FliP -
BHL98_RS00530 121584..121856 + 273 WP_004199882.1 flagellar biosynthesis protein FliQ -
BHL98_RS00535 121975..122757 + 783 WP_004201278.1 flagellar biosynthetic protein FliR -
BHL98_RS00540 123077..123505 - 429 WP_004199881.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliP / fliQ / fliR 116966..140908 23942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T66111 WP_004199884.1 NZ_CP017175:c119031-118735 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T66111 NZ_CP017175:c119031-118735 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT66111 WP_004202809.1 NZ_CP017175:c118732-118376 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT66111 NZ_CP017175:c118732-118376 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References