Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2740988..2742587 Replicon chromosome
Accession NZ_CP017168
Organism Bordetella pertussis strain J310

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag BHR59_RS13300 Protein ID WP_003816876.1
Coordinates 2740988..2742328 (-) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BHR59_RS13305 Protein ID WP_019247974.1
Coordinates 2742330..2742587 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHR59_RS13280 2736214..2737035 - 822 WP_014905903.1 IclR family transcriptional regulator -
BHR59_RS13285 2737450..2738528 - 1079 Protein_2583 tellurite resistance/C4-dicarboxylate transporter family protein -
BHR59_RS13290 2738760..2740190 - 1431 WP_019247976.1 MFS transporter -
BHR59_RS13295 2740203..2740892 + 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
BHR59_RS13300 2740988..2742328 - 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
BHR59_RS13305 2742330..2742587 - 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
BHR59_RS13315 2742941..2744533 - 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
BHR59_RS13320 2744630..2746090 - 1461 WP_003812368.1 IMP dehydrogenase -
BHR59_RS13325 2746313..2746924 + 612 WP_010931041.1 DUF2239 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T66110 WP_003816876.1 NZ_CP017168:c2742328-2740988 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

>T66110 NZ_CP017168:c2742328-2740988 [Bordetella pertussis]
ATGGGGCGCCGATCGCACAGCCGCAGCCTGTCCATCTGGACCAACGGCGTTCGCGTCGGGCGTTGGACGGTTCCCGCTCG
CGGAGAGATGGAACTGCAGTACGACGTGGATTGGGTCCGTGCCGACGTCGGCCGGCCACTTTCGCTGTCGCTGCCATTCA
ACTTGCAGAATCTGCCCCTCAAGGGGGAGAGAGTCGCCAACTACTTCGACAATCTGCTACCGGACAGCGACGCTATCCGT
CGTCGCGTGGCCGAGCGATTCAGGACGGGCTCGGTCGATCCCTTCGATCTGTTGAAAGCCATTGGACGCGATTGCGTTGG
CGCCGTACAGATCCTGGAAGACGAAGAGATACCTGAGGGCTTTGATCGCATCGAGGGCGTGCCTCTGTCCGAGGAGGACA
TCGAGCGGCATTTGATCGAAACCGTTACGCCGCGCGCCTTCGCTGCGGGCCGGGACCCGGACGCGGATTTCAGAATTTCT
CTGGCCGGCGCGCAAGAGAAGACAGCCTTCCTGTGGTGGGGCGGACAGTGGCTTGCGCCGCGTGGCGCGACATCGACGAG
CCATATTTTCAAACTTCCATTGGGCTTGGTGGGTGGACGGCGGGCTGACTTCAGCACTTCTGTTGATAACGAATGGCTGT
GTCTGAAGCTGCTGAAGGCGTATGGGTTGGATGTGGCTGAGGCCAGCATCGCAACCTTCGGACAGCAGCGAGTGCTGGTG
GTCGAGCGATTCGACCGGCGTGTTGCGCCCAACGGGCAATGGCTGATGCGCCTGCCGCAGGAAGATTTCTGCCAGGTCGA
GGGGTGCTCGCCGCTACGCAAGTATGAAAACGAGGGCGGCCCAGGACTCAAGGCCTTATTCGCCACGCTGCGGCAGTCAG
TGAACGCAGCGGTCGATATGAGAACGTTGATGGCGGCGCAGATCCTGTTTTGGTTGCTGCGGGCACCCGATGGCCACGCC
AAGAATTTCAGCATCCAGTTGTTGCCGCGCGGCCGTTTCCAGTTGACTAGACTGTACGACGTGATGTCGGCCTATCCGGT
ACTGGGCGATGGCGCGAATCAGTGGTCGCCGTTCGAAATCAAATTGGCGATGGCATTGATTGGCAAGAACCGGCATTACG
AGATGCACGGCATCCAGCGCAGGCACTTCAACAGCACCGCACAAAAAGTTGGTTATGGCCCGACGGCGGAGCCGATCATT
GAAGACCTGTTGGCCCGTACGCCCGCGATCATTGCCGCCGTGCAGGCCGATTTGCCGCAGGACTTCTCGCCGCGTGTTGC
GGACTCCGTCCTGGGTGGGCTTGCGCAGGCCGCAAAGTCGCTCGGCGCAATGATGCCGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT66110 WP_019247974.1 NZ_CP017168:c2742587-2742330 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp

>AT66110 NZ_CP017168:c2742587-2742330 [Bordetella pertussis]
ATGCCGCCGCCATCACAACCTCTGCTCACTACCGGCCAGCTTGGCGCGGTCTTGCAGGCTGCACGCAAAGCACAGGGACT
GACTCAATCGGCCCTGGCCAGTCGTATCGGCCTGAGCCAATCGCGGGTCTCGCACCTGGAGTTGAATGCCCATCAACTGA
GCGTGGAGCAGCTCCTGGCCTGGTGCGCGGCGCTAGGGTTGGAGTTGACGATTGCGACTCGCGGAAGTCCCGCAGGGTCT
TCCGACGCGGATTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References