66092

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2371541..2372050 Replicon chromosome
Accession NZ_CP017156
Organism Macrococcus sp. IME1552

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BHM04_RS12355 Protein ID WP_096078043.1
Coordinates 2371688..2372050 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BHM04_RS12685 Protein ID WP_165958642.1
Coordinates 2371541..2371687 (+) Length 49 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHM04_RS12330 2367502..2367981 + 480 WP_157742257.1 PH domain-containing protein -
BHM04_RS12335 2367968..2369473 + 1506 WP_096078039.1 PH domain-containing protein -
BHM04_RS12340 2369466..2369945 + 480 WP_096078040.1 PH domain-containing protein -
BHM04_RS12345 2369938..2370276 + 339 WP_096078041.1 holo-ACP synthase -
BHM04_RS12350 2370333..2371478 + 1146 WP_096078042.1 alanine racemase -
BHM04_RS12685 2371541..2371687 + 147 WP_165958642.1 hypothetical protein Antitoxin
BHM04_RS12355 2371688..2372050 + 363 WP_096078043.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BHM04_RS12360 2372100..2373107 + 1008 WP_096078044.1 PP2C family protein-serine/threonine phosphatase -
BHM04_RS12365 2373197..2373523 + 327 WP_096078045.1 anti-sigma factor antagonist -
BHM04_RS12370 2373525..2373965 + 441 WP_096078046.1 anti-sigma B factor RsbW -
BHM04_RS12375 2373976..2374743 + 768 WP_096078047.1 RNA polymerase sigma factor SigB -
BHM04_RS12380 2374824..2376974 + 2151 WP_096078048.1 RNA-binding transcriptional accessory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13231.30 Da        Isoelectric Point: 7.3168

>T66092 WP_096078043.1 NZ_CP017156:2371688-2372050 [Macrococcus sp. IME1552]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNDIGNKYSPTVIVAAITAKINKSKIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTYLPKEKMEEVDAALAISLNLSIDDSETLG

Download         Length: 363 bp

>T66092 NZ_CP017156:2371688-2372050 [Macrococcus sp. IME1552]
ATGAAACGAGGCGATGTTTATTTAGCTGATTTGTCACCTGTTAAAGGTTCAGAGCAAGGCGGTAAACGACCTGTAGTAAT
CATTCAAAATGACATAGGAAATAAATATAGTCCGACGGTTATAGTTGCAGCTATCACTGCTAAAATCAATAAATCAAAAA
TCCCAACGCACGTAGAGATTGGTAAGACCAATCATCATCTAGATAAAGATTCTGTGATTTTATTAGAACAAATAAGAACA
ATTGATAAAAATCGACTTATTGAAAAATTGACTTACCTGCCAAAAGAGAAGATGGAGGAAGTTGATGCAGCACTAGCAAT
TAGTCTTAATTTATCTATTGATGACTCGGAGACTTTAGGCTAA

Antitoxin


Download         Length: 49 a.a.        Molecular weight: 5544.19 Da        Isoelectric Point: 3.7510

>AT66092 WP_165958642.1 NZ_CP017156:2371541-2371687 [Macrococcus sp. IME1552]
MSKLLEQQLIEGYQSMAEINLLIASEHYLLECEVYDNVDHMSVQNDGE

Download         Length: 147 bp

>AT66092 NZ_CP017156:2371541-2371687 [Macrococcus sp. IME1552]
ATGAGTAAACTACTAGAACAACAATTGATTGAAGGTTATCAATCAATGGCTGAAATTAATCTGTTAATTGCTTCAGAACA
TTATCTCCTTGAATGTGAAGTGTATGATAATGTGGATCATATGTCAGTACAAAATGATGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References