Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 175196..175963 Replicon chromosome
Accession NZ_CP017156
Organism Macrococcus sp. IME1552

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag BHM04_RS12615 Protein ID WP_165958672.1
Coordinates 175820..175963 (+) Length 48 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag BHM04_RS00985 Protein ID WP_096075978.1
Coordinates 175196..175807 (+) Length 204 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHM04_RS00960 170245..171651 + 1407 WP_096078059.1 ABC transporter permease subunit -
BHM04_RS00965 171644..172366 + 723 WP_096075974.1 amino acid ABC transporter ATP-binding protein -
BHM04_RS00970 172517..173641 + 1125 WP_096075975.1 tRNA epoxyqueuosine(34) reductase QueG -
BHM04_RS00975 173642..174115 + 474 WP_096075976.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
BHM04_RS00980 174128..174865 + 738 WP_096075977.1 oxygen-insensitive NADPH nitroreductase -
BHM04_RS00985 175196..175807 + 612 WP_096075978.1 glucosamine-6-phosphate isomerase Antitoxin
BHM04_RS12615 175820..175963 + 144 WP_165958672.1 hypothetical protein Toxin
BHM04_RS00990 176074..177459 + 1386 WP_096075979.1 class II fumarate hydratase -
BHM04_RS00995 177490..179022 + 1533 WP_096075980.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5413.64 Da        Isoelectric Point: 3.6118

>T66089 WP_165958672.1 NZ_CP017156:175820-175963 [Macrococcus sp. IME1552]
MSTSHDNKNEMVTDFDDVVELGKEMEQISEQNAEAREEGQEQEDDPQ

Download         Length: 144 bp

>T66089 NZ_CP017156:175820-175963 [Macrococcus sp. IME1552]
ATGTCAACATCACATGATAATAAAAATGAAATGGTAACTGATTTCGACGACGTTGTAGAATTAGGTAAAGAGATGGAGCA
AATCTCTGAACAAAATGCTGAAGCGCGAGAAGAAGGCCAGGAACAAGAGGATGATCCTCAATAA

Antitoxin


Download         Length: 204 a.a.        Molecular weight: 22525.50 Da        Isoelectric Point: 5.3614

>AT66089 WP_096075978.1 NZ_CP017156:175196-175807 [Macrococcus sp. IME1552]
MAMNFKIFEDKLTVSNYVADLFRKQMSNNPTSIIATALGDEAGHVIAELKANIARNPVETSQIHIFDYDKLRGDYGTVGI
VDKQYHEATGKDIMELIKDEAKTKENKGKLTTLFATITQDGSVGYKEINQDNDKGLRSAREIIIVLTGADKASIVEKLYN
TEAGGNFEAANLKTHRMVNVILDDAAAAGLPQDIREYYFQKFA

Download         Length: 612 bp

>AT66089 NZ_CP017156:175196-175807 [Macrococcus sp. IME1552]
ATGGCAATGAATTTTAAAATTTTTGAAGATAAATTAACCGTATCGAACTACGTTGCTGATTTATTTAGAAAGCAGATGAG
TAACAATCCGACATCAATTATCGCGACTGCTTTAGGTGATGAAGCAGGTCACGTCATTGCAGAATTAAAGGCTAATATCG
CTCGTAATCCAGTTGAGACGAGTCAAATTCATATCTTTGACTATGATAAATTACGTGGTGATTATGGCACTGTTGGTATC
GTTGATAAACAATACCATGAAGCAACAGGTAAAGATATTATGGAATTGATTAAAGACGAAGCGAAGACTAAAGAGAACAA
AGGGAAGTTGACAACTTTATTTGCTACGATTACACAAGATGGCTCTGTCGGTTATAAAGAGATTAATCAGGATAACGATA
AAGGTTTACGTTCAGCACGTGAAATTATTATCGTATTAACAGGTGCAGACAAAGCTTCAATCGTTGAAAAACTATACAAT
ACTGAAGCGGGTGGCAACTTTGAAGCAGCGAATTTAAAAACACATCGCATGGTCAATGTTATCTTAGATGATGCAGCAGC
AGCTGGATTACCTCAAGATATACGTGAATACTACTTCCAAAAATTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References