Detailed information of TA system TA066087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2536037..2536716
• Replicon: chromosome
• Accession: NZ_CP017152
• Organism: Acinetobacter baumannii DU202

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: DU202_RS12510
• Protein ID: WP_000838146.1
• Coordinates: 2536534..2536716 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: DU202_RS12505
• Protein ID: WP_000966688.1
• Coordinates: 2536037..2536441 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DU202_RS12495	2534993..2535256	-	264	WP_001275792.1	hypothetical protein	-
DU202_RS12500	2535258..2535938	-	681	WP_000721572.1	hypothetical protein	-
DU202_RS12505	2536037..2536441	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DU202_RS12510	2536534..2536716	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
DU202_RS12515	2537042..2537557	-	516	WP_024616020.1	hypothetical protein	-
DU202_RS21475	2537628..2538546	-	919	Protein_2462	hypothetical protein	-
DU202_RS12525	2538599..2539954	-	1356	WP_000002415.1	hypothetical protein	-
DU202_RS12530	2539954..2540307	-	354	WP_000064593.1	hypothetical protein	-
DU202_RS12535	2540404..2540925	-	522	WP_000749909.1	SH3 domain-containing protein	-
DU202_RS12540	2541034..2541252	-	219	WP_001277696.1	hypothetical protein	-
DU202_RS12545	2541254..2541697	-	444	WP_002016455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2512258..2575299	63041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T66087 WP_000838146.1 NZ_CP017152:c2536716-2536534 [Acinetobacter baumannii DU202]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T66087 NZ_CP017152:c2536716-2536534 [Acinetobacter baumannii DU202]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT66087 WP_000966688.1 NZ_CP017152:c2536441-2536037 [Acinetobacter baumannii DU202]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT66087 NZ_CP017152:c2536441-2536037 [Acinetobacter baumannii DU202]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6