Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143090..143595 Replicon chromosome
Accession NZ_CP017149
Organism Pseudomonas aeruginosa strain ATCC 15692

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag BGV84_RS00635 Protein ID WP_003083773.1
Coordinates 143090..143371 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag BGV84_RS00640 Protein ID WP_003112628.1
Coordinates 143368..143595 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGV84_RS00610 138341..139690 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
BGV84_RS00615 139739..140425 + 687 WP_003083762.1 FadR family transcriptional regulator -
BGV84_RS00620 140526..141260 + 735 WP_003115036.1 GntR family transcriptional regulator -
BGV84_RS00625 141464..141850 + 387 WP_014602345.1 aegerolysin family protein -
BGV84_RS00630 141882..142790 - 909 WP_003083769.1 LysR family transcriptional regulator -
BGV84_RS00635 143090..143371 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
BGV84_RS00640 143368..143595 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
BGV84_RS00645 143771..144391 - 621 WP_003101226.1 hypothetical protein -
BGV84_RS00650 144492..144992 + 501 WP_003112629.1 LEA type 2 family protein -
BGV84_RS00655 145065..145406 + 342 WP_003101229.1 alkylphosphonate utilization protein -
BGV84_RS00660 145488..146915 - 1428 WP_003083784.1 GABA permease -
BGV84_RS00665 147084..148577 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T66077 WP_003083773.1 NZ_CP017149:c143371-143090 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T66077 NZ_CP017149:c143371-143090 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT66077 WP_003112628.1 NZ_CP017149:c143595-143368 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT66077 NZ_CP017149:c143595-143368 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References