Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 4560914..4561559 Replicon chromosome
Accession NZ_CP017147
Organism Bosea vaviloviae strain Vaf18

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag BHK69_RS31615 Protein ID WP_083269881.1
Coordinates 4561227..4561559 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1D7U5B7
Locus tag BHK69_RS20895 Protein ID WP_069691777.1
Coordinates 4560914..4561234 (-) Length 107 a.a.

Genomic Context

BHK69_RS20880BHK69_RS20885BHK69_RS20905BHK69_RS32720BHK69_RS20875BHK69_RS20890BHK69_RS20895BHK69_RS31615BHK69_RS32715BHK69_RS20920
Location: 4558395..4559264 (870 bp)
Type: Others
Protein ID: WP_069691774.1
Location: 4559350..4560459 (1110 bp)
Type: Others
Protein ID: WP_158516253.1
Location: 4561671..4562954 (1284 bp)
Type: Others
Protein ID: WP_069691779.1
Location: 4563972..4564961 (990 bp)
Type: Others
Protein ID: WP_069691781.1
Location: 4557755..4558096 (342 bp)
Type: Others
Protein ID: WP_069693843.1
Location: 4560462..4560917 (456 bp)
Type: Others
Protein ID: WP_148663523.1
Location: 4560914..4561234 (321 bp)
Type: Antitoxin
Protein ID: WP_069691777.1
Location: 4561227..4561559 (333 bp)
Type: Toxin
Protein ID: WP_083269881.1
Location: 4563075..4563773 (699 bp)
Type: Others
Protein ID: WP_069691780.1
Location: 4564884..4565633 (750 bp)
Type: Others
Protein ID: WP_069693844.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BHK69_RS208754557755..4558096-342WP_069693843.1ATP-dependent Clp protease adapter ClpS-
BHK69_RS208804558395..4559264+870WP_069691774.13-deoxy-8-phosphooctulonate synthase-
BHK69_RS208854559350..4560459+1110WP_158516253.1MFS transporter-
BHK69_RS208904560462..4560917-456WP_148663523.1preQ(1) synthase-
BHK69_RS208954560914..4561234-321WP_069691777.1putative addiction module antidote proteinAntitoxin
BHK69_RS316154561227..4561559-333WP_083269881.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BHK69_RS209054561671..4562954+1284WP_069691779.1phosphopyruvate hydratase-
BHK69_RS327154563075..4563773-699WP_069691780.1hypothetical protein-
BHK69_RS327204563972..4564961+990WP_069691781.1DMT family transporter-
BHK69_RS209204564884..4565633-750WP_069693844.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(28-99)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12537.35 Da        Isoelectric Point: 10.5722

>T66075 WP_083269881.1 NZ_CP017147:c4561559-4561227 [Bosea vaviloviae]
IVFYKLQTVTLHLKQTETFRKWERRLKDAKARAAIAARLFRLANGLTGDVSAVGGGVSEIRIHHGPGYRVYFRRRGDQII
ILLCGGDKSTQERDIRAAKQLAAEWEDRDD

Download         Length: 333 bp

>T66075 NZ_CP017147:c4561559-4561227 [Bosea vaviloviae]
ATTGTATTTTATAAATTACAAACCGTCACGCTTCATCTCAAGCAGACTGAGACATTTCGCAAATGGGAGCGCAGGCTCAA
GGACGCCAAGGCAAGAGCAGCCATCGCTGCACGCCTCTTTCGTCTCGCCAATGGTCTCACAGGGGACGTCTCCGCAGTCG
GCGGTGGCGTCAGTGAAATCCGCATTCACCACGGCCCCGGCTATCGCGTCTATTTCCGGAGGCGCGGTGACCAGATCATC
ATCCTGCTGTGCGGTGGCGACAAAAGCACGCAAGAGCGCGATATCAGGGCGGCAAAGCAACTGGCTGCGGAATGGGAGGA
TCGGGATGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11402.87 Da        Isoelectric Point: 4.6437

>AT66075 WP_069691777.1 NZ_CP017147:c4561234-4560914 [Bosea vaviloviae]
MTDKLDDYDPADALKSDEAVELFLDDAFASGNARYIAQALGVVARAKGMTKIARETGLAREQLYKSLSENGNPTLETTLA
VLKAIGFEMTGKRHVASPDPLQSLTS

Download         Length: 321 bp

>AT66075 NZ_CP017147:c4561234-4560914 [Bosea vaviloviae]
ATGACTGACAAACTCGATGATTACGACCCCGCGGATGCGCTGAAATCCGATGAAGCGGTCGAACTCTTCCTCGACGATGC
CTTTGCCAGCGGCAATGCGCGCTATATCGCGCAGGCGCTTGGCGTCGTCGCTCGTGCGAAGGGAATGACAAAGATCGCTC
GCGAGACCGGGTTGGCGCGCGAGCAGCTCTACAAGTCGCTCAGCGAAAACGGCAATCCGACGCTAGAAACCACATTGGCT
GTGCTAAAGGCGATCGGATTCGAAATGACCGGCAAGCGACATGTCGCATCGCCAGACCCCCTGCAGAGCCTGACATCATG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1D7U5B7

References