Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3085528..3086330 Replicon chromosome
Accession NZ_CP017147
Organism Bosea vaviloviae strain Vaf18

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A1D7U256
Locus tag BHK69_RS14210 Protein ID WP_069690668.1
Coordinates 3085803..3086330 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A1D7U263
Locus tag BHK69_RS14205 Protein ID WP_069690667.1
Coordinates 3085528..3085806 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHK69_RS14180 3081374..3082345 - 972 WP_069690663.1 LysR family transcriptional regulator -
BHK69_RS14185 3082446..3083006 + 561 WP_069690664.1 phosphonopyruvate decarboxylase -
BHK69_RS14190 3083027..3083614 + 588 WP_069693657.1 aldehyde dehydrogenase -
BHK69_RS14195 3084059..3084871 + 813 WP_069690665.1 SDR family oxidoreductase -
BHK69_RS14200 3084868..3085314 + 447 WP_069690666.1 VOC family protein -
BHK69_RS14205 3085528..3085806 + 279 WP_069690667.1 DUF1778 domain-containing protein Antitoxin
BHK69_RS14210 3085803..3086330 + 528 WP_069690668.1 GNAT family N-acetyltransferase Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-89)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18949.77 Da        Isoelectric Point: 7.3745

>T66074 WP_069690668.1 NZ_CP017147:3085803-3086330 [Bosea vaviloviae]
VSLPAWHEEPITKAHDRKAFDCGVSELNRFLERFARQGHEHNAVKTFCAIADDTPNKVLGFYSLTPTSIAYEAVPPAMTR
GLARHRVAGFLLARLAVDKTVGGQGLGGQLLLAAALRCLRVTVEVGGVLLIIDAKDDRAAQWYCSFGAERAADQPLTLVA
PLTTFAEALRETGHL

Download         Length: 528 bp

>T66074 NZ_CP017147:3085803-3086330 [Bosea vaviloviae]
GTGAGCCTTCCCGCCTGGCATGAGGAGCCGATCACGAAGGCGCATGATCGAAAGGCCTTCGACTGCGGTGTGAGCGAGCT
GAATAGGTTCCTCGAGCGGTTTGCCCGGCAAGGGCATGAGCACAACGCCGTGAAGACGTTTTGCGCAATCGCGGACGACA
CACCCAACAAGGTCCTGGGGTTCTATAGCCTTACCCCAACCTCGATCGCATACGAGGCGGTTCCCCCTGCCATGACCAGG
GGGCTGGCCCGCCATAGGGTGGCTGGCTTCCTGCTCGCGCGGCTTGCCGTCGACAAGACCGTCGGCGGCCAAGGCCTCGG
CGGGCAGCTCCTCCTTGCGGCGGCTTTGCGTTGCCTGCGGGTGACGGTGGAAGTCGGCGGAGTTTTGCTGATCATCGACG
CCAAAGATGACCGCGCCGCGCAATGGTATTGCAGCTTTGGCGCGGAGCGAGCCGCCGACCAGCCGCTCACTCTGGTTGCG
CCACTGACCACCTTCGCTGAAGCGCTTCGCGAAACAGGGCACCTTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10098.73 Da        Isoelectric Point: 11.0037

>AT66074 WP_069690667.1 NZ_CP017147:3085528-3085806 [Bosea vaviloviae]
MARTALDDTNRMNLRIKPDAKARLMRAAALRHTDLTSFVTQSALRAADAVIAEADVTKVSERDFFRILELLDNPPKPNAR
LKAAAAALPKSL

Download         Length: 279 bp

>AT66074 NZ_CP017147:3085528-3085806 [Bosea vaviloviae]
ATGGCACGCACCGCCCTTGACGACACAAATCGGATGAACCTCCGCATCAAGCCGGACGCGAAGGCGCGGCTGATGCGTGC
GGCTGCTCTGCGCCATACCGATCTGACCAGTTTCGTCACCCAGTCCGCCCTGCGCGCGGCCGATGCCGTCATCGCTGAAG
CCGATGTGACCAAGGTGTCGGAGCGTGACTTTTTTCGGATCCTGGAATTGCTGGACAACCCGCCAAAGCCGAATGCGAGG
TTGAAAGCCGCCGCCGCCGCCTTGCCGAAGTCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7U256

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7U263

References