Detailed information of TA system TA066073

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2939499..2940055
• Replicon: chromosome
• Accession: NZ_CP017147
• Organism: Bosea vaviloviae strain Vaf18

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BHK69_RS31395
• Protein ID: WP_083269369.1
• Coordinates: 2939499..2939789 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1D7U1V2
• Locus tag: BHK69_RS13520
• Protein ID: WP_069690560.1
• Coordinates: 2939777..2940055 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BHK69_RS13500	2934984..2936057	+	1074	WP_148663404.1	alkene reductase	-
BHK69_RS13505	2936072..2937058	+	987	WP_083269367.1	SDR family oxidoreductase	-
BHK69_RS13510	2937534..2938535	+	1002	WP_083269368.1	tRNA dihydrouridine(20/20a) synthase DusA	-
BHK69_RS13515	2938646..2939101	+	456	WP_069693629.1	PaaI family thioesterase	-
BHK69_RS31395	2939499..2939789	-	291	WP_083269369.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BHK69_RS13520	2939777..2940055	-	279	WP_069690560.1	CopG family ribbon-helix-helix protein	Antitoxin
BHK69_RS13525	2940276..2941481	-	1206	WP_083269371.1	sugar ABC transporter permease	-
BHK69_RS13530	2941478..2943028	-	1551	WP_069690561.1	sugar ABC transporter ATP-binding protein	-
BHK69_RS13535	2943224..2944291	-	1068	WP_069690562.1	sugar-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10723.24 Da
• Isoelectric Point: 9.6540

>T66073 WP_083269369.1 NZ_CP017147:c2939789-2939499 [Bosea vaviloviae]
MPRVVFAPAAVRDLERLRAFLRSKDPSAAKRAGETIIAGTQALGTHPRMGRLVEDLPEQYREWLIDFGDSGYVVRYRVDS
DAVTILAVRHQKEAGS

Nucleotide

• Length: 291 bp

>T66073 NZ_CP017147:c2939789-2939499 [Bosea vaviloviae]
ATGCCACGAGTAGTTTTCGCGCCTGCAGCGGTTCGCGATCTCGAGCGACTGCGCGCCTTCCTTCGCTCCAAGGACCCATC
AGCCGCCAAACGGGCGGGCGAGACGATCATCGCAGGCACGCAAGCACTCGGCACGCATCCTCGCATGGGCCGGCTTGTCG
AGGATCTACCCGAGCAATACCGGGAATGGCTCATCGATTTTGGGGATAGCGGATATGTGGTTCGCTATCGTGTTGACAGC
GACGCTGTAACAATCCTCGCGGTGCGGCACCAAAAGGAAGCGGGATCATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10606.87 Da
• Isoelectric Point: 5.2082

>AT66073 WP_069690560.1 NZ_CP017147:c2940055-2939777 [Bosea vaviloviae]
MAAVTSIKLDDELKGRVQNLAAARRRTSHWIMREAIEQYVAREEKHEALRQDTVKAWEEFQATGLRATADEVEKWLSSWG
SENELPTPVCHE

Nucleotide

• Length: 279 bp

>AT66073 NZ_CP017147:c2940055-2939777 [Bosea vaviloviae]
ATGGCAGCGGTCACATCCATCAAGCTTGACGATGAACTGAAGGGCCGTGTGCAGAACCTGGCCGCGGCGCGTCGGCGCAC
GTCTCATTGGATCATGCGCGAGGCAATTGAGCAGTACGTGGCGCGTGAAGAGAAGCACGAAGCGTTGCGACAAGACACAG
TTAAGGCCTGGGAGGAATTTCAAGCCACCGGCTTGCGCGCAACGGCTGATGAGGTCGAAAAGTGGTTGTCGAGTTGGGGG
TCTGAAAACGAACTGCCCACGCCGGTATGCCACGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1D7U1V2