Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2392376..2392965 Replicon chromosome
Accession NZ_CP017147
Organism Bosea vaviloviae strain Vaf18

Toxin (Protein)


Gene name relE Uniprot ID A0A1D7U0S2
Locus tag BHK69_RS11175 Protein ID WP_069690167.1
Coordinates 2392678..2392965 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1D7U0P6
Locus tag BHK69_RS11170 Protein ID WP_069690166.1
Coordinates 2392376..2392681 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHK69_RS11150 2388579..2389190 - 612 WP_069690163.1 ribonuclease HII -
BHK69_RS11155 2389382..2390467 - 1086 WP_069693563.1 PA0069 family radical SAM protein -
BHK69_RS11160 2390726..2391214 + 489 WP_148663377.1 glycosyltransferase family 2 protein -
BHK69_RS11165 2391351..2392235 - 885 WP_069690165.1 neutral zinc metallopeptidase -
BHK69_RS11170 2392376..2392681 + 306 WP_069690166.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BHK69_RS11175 2392678..2392965 + 288 WP_069690167.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BHK69_RS11180 2393003..2394007 - 1005 WP_069690168.1 cytochrome d ubiquinol oxidase subunit II -
BHK69_RS11185 2394021..2395451 - 1431 WP_069690169.1 cytochrome ubiquinol oxidase subunit I -
BHK69_RS11190 2395788..2396594 - 807 WP_148663657.1 uracil-DNA glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10750.33 Da        Isoelectric Point: 5.6993

>T66071 WP_069690167.1 NZ_CP017147:2392678-2392965 [Bosea vaviloviae]
VRLDWSVLAVADRERIFDYVATDNPRAAVALDERIEQHVEVLLAFPESGRPGRVEGTRELIVGGTPYIAAYRIDSRAIRI
LRILHMSQLWPDGLP

Download         Length: 288 bp

>T66071 NZ_CP017147:2392678-2392965 [Bosea vaviloviae]
GTGAGGCTCGATTGGAGCGTGCTCGCGGTCGCCGATCGCGAGCGTATCTTCGATTATGTCGCAACCGACAATCCGCGTGC
CGCCGTCGCGCTCGACGAGCGCATCGAGCAGCATGTGGAGGTGCTGCTGGCCTTTCCGGAGAGCGGCCGTCCCGGCCGTG
TCGAAGGAACGCGCGAACTCATCGTCGGCGGCACGCCCTATATCGCGGCCTACCGCATCGACAGCAGAGCGATCCGAATC
CTGCGCATCCTGCATATGTCGCAGCTCTGGCCGGACGGATTGCCCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10923.50 Da        Isoelectric Point: 8.8254

>AT66071 WP_069690166.1 NZ_CP017147:2392376-2392681 [Bosea vaviloviae]
MAASDLVQARIDPRVKERAAAVLQEAGLTVSDAVRILLTRTANEGALPLELIDPARHEAWFRAKVLEALADTSPATDHAE
VKARFAEKRRAALARTPDAKA

Download         Length: 306 bp

>AT66071 NZ_CP017147:2392376-2392681 [Bosea vaviloviae]
ATGGCAGCAAGCGATCTCGTTCAAGCCCGTATCGATCCGCGTGTGAAGGAACGGGCGGCGGCCGTTCTGCAGGAGGCGGG
GCTGACCGTCTCGGACGCGGTGCGAATCCTGCTGACCAGAACCGCCAATGAGGGCGCTCTGCCCCTGGAGCTGATCGACC
CGGCCCGGCACGAGGCGTGGTTCCGTGCGAAGGTGCTCGAGGCGCTCGCCGATACCAGCCCCGCGACGGATCATGCCGAG
GTCAAGGCTCGCTTCGCCGAGAAGCGCCGGGCGGCCCTGGCGCGCACGCCGGACGCCAAGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7U0S2

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7U0P6

References