Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 1278143..1278680 Replicon chromosome
Accession NZ_CP017147
Organism Bosea vaviloviae strain Vaf18

Toxin (Protein)


Gene name parE Uniprot ID A0A1D7TY91
Locus tag BHK69_RS06065 Protein ID WP_069689319.1
Coordinates 1278390..1278680 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1D7TYB1
Locus tag BHK69_RS06060 Protein ID WP_069689318.1
Coordinates 1278143..1278400 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHK69_RS31305 1273335..1274174 + 840 WP_083269152.1 endonuclease/exonuclease/phosphatase family protein -
BHK69_RS06040 1274346..1275191 - 846 WP_083269805.1 tetratricopeptide repeat protein -
BHK69_RS06045 1275339..1276730 + 1392 WP_148663644.1 leucyl aminopeptidase family protein -
BHK69_RS06050 1276829..1277182 + 354 WP_069689316.1 MarR family transcriptional regulator -
BHK69_RS06055 1277229..1278086 + 858 WP_069689317.1 C40 family peptidase -
BHK69_RS06060 1278143..1278400 + 258 WP_069689318.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BHK69_RS06065 1278390..1278680 + 291 WP_069689319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHK69_RS06070 1278699..1281443 - 2745 WP_069689320.1 DNA mismatch repair protein MutS -
BHK69_RS06075 1281641..1283476 + 1836 WP_069689321.1 PAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Antitoxin ParD

(6-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11058.59 Da        Isoelectric Point: 6.0741

>T66069 WP_069689319.1 NZ_CP017147:1278390-1278680 [Bosea vaviloviae]
MAVRRTPRADQDLVGIYLEGVGQFGQRQAEIYAANLSSCFELLASQPLMARERTEIQPPVRVHAHGSHIIVYAVDEEDIL
IMRVLHGRRDWEREFQ

Download         Length: 291 bp

>T66069 NZ_CP017147:1278390-1278680 [Bosea vaviloviae]
ATGGCGGTTAGGCGAACGCCGCGAGCCGACCAGGATCTGGTCGGGATTTATCTCGAAGGCGTCGGGCAATTCGGGCAAAG
GCAAGCCGAGATTTACGCGGCCAACCTTAGTTCATGCTTCGAATTGCTCGCCTCCCAGCCTTTGATGGCGCGAGAGCGAA
CGGAAATTCAACCGCCGGTCCGGGTGCATGCCCATGGCAGTCATATCATCGTCTACGCAGTCGATGAGGAGGACATCCTG
ATCATGCGCGTCCTGCACGGCCGTCGCGATTGGGAACGCGAGTTTCAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9642.70 Da        Isoelectric Point: 4.8660

>AT66069 WP_069689318.1 NZ_CP017147:1278143-1278400 [Bosea vaviloviae]
MATMNVSLPDQMKAWVETQAESGRYGNASDYVRDLIRRDQERQDKIAAFQRLIDEGRASGVSTRALDEVWEEARRRAKEL
GLDGG

Download         Length: 258 bp

>AT66069 NZ_CP017147:1278143-1278400 [Bosea vaviloviae]
ATGGCGACGATGAACGTGTCCCTACCCGACCAGATGAAGGCCTGGGTCGAGACGCAGGCCGAGAGCGGCCGCTACGGCAA
CGCCAGCGACTATGTCCGCGACCTGATCCGGCGCGACCAGGAGCGGCAGGACAAGATCGCAGCATTCCAGCGGCTGATCG
ATGAAGGCCGCGCTAGCGGCGTCAGCACGCGGGCTTTGGACGAGGTCTGGGAGGAGGCCCGTCGCCGCGCCAAAGAGCTT
GGCCTCGATGGCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7TY91

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7TYB1

References