Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1057202..1058013 Replicon chromosome
Accession NZ_CP017147
Organism Bosea vaviloviae strain Vaf18

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1D7TXS8
Locus tag BHK69_RS05005 Protein ID WP_069689146.1
Coordinates 1057202..1057711 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1D7U9Z5
Locus tag BHK69_RS05010 Protein ID WP_069693383.1
Coordinates 1057714..1058013 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHK69_RS04980 1052706..1054040 - 1335 WP_148663640.1 ActS/PrrB/RegB family redox-sensitive histidine kinase -
BHK69_RS04985 1054249..1055550 + 1302 WP_083269793.1 polyhydroxyalkanoate depolymerase -
BHK69_RS04990 1055572..1055970 - 399 WP_069689143.1 type II toxin-antitoxin system VapC family toxin -
BHK69_RS04995 1055970..1056209 - 240 WP_069689144.1 type II toxin-antitoxin system VapB family antitoxin -
BHK69_RS05000 1056452..1057192 + 741 WP_069689145.1 M48 family metallopeptidase -
BHK69_RS05005 1057202..1057711 - 510 WP_069689146.1 GNAT family N-acetyltransferase Toxin
BHK69_RS05010 1057714..1058013 - 300 WP_069693383.1 DUF1778 domain-containing protein Antitoxin
BHK69_RS05015 1058149..1059345 + 1197 WP_069689147.1 multidrug effflux MFS transporter -
BHK69_RS05020 1059553..1061712 - 2160 WP_069689148.1 PBP1A family penicillin-binding protein -
BHK69_RS05025 1062042..1062440 + 399 WP_069689149.1 DoxX family protein -
BHK69_RS05030 1062528..1062848 - 321 WP_069689150.1 thioredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-144)

Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18358.15 Da        Isoelectric Point: 10.6439

>T66068 WP_069689146.1 NZ_CP017147:c1057711-1057202 [Bosea vaviloviae]
MVSAPEPLSEQHDLSTFDCGKPALDQWLRQRALSNHHKGFTAVMVIQSERRVIGYYGLAPTAITPTALSRSLRTGQPPDP
VPCLLLGQLATDRRWSGQGIGTGLLKHAFGRCVQVAGLIGGRALLVRAIDDEARSFWLRRGFVPSNSDPMMLARSLQDIA
VSVRSGARA

Download         Length: 510 bp

>T66068 NZ_CP017147:c1057711-1057202 [Bosea vaviloviae]
TTGGTTTCCGCTCCGGAGCCTCTTTCAGAGCAGCACGATCTGTCGACATTCGACTGCGGCAAGCCGGCGCTCGACCAATG
GCTGAGGCAGCGTGCCTTGTCGAACCATCACAAGGGCTTCACCGCAGTCATGGTGATTCAATCCGAGCGGCGCGTGATCG
GCTATTACGGCCTGGCTCCCACGGCCATTACACCGACCGCATTGTCGCGCTCACTGCGGACCGGTCAACCGCCGGACCCG
GTTCCATGCCTGCTGTTGGGCCAATTGGCGACCGACCGTCGCTGGAGTGGTCAAGGCATCGGAACAGGACTGCTCAAGCA
TGCATTCGGGCGCTGTGTTCAGGTTGCCGGACTGATCGGCGGCCGGGCTCTTCTGGTTCGAGCCATCGACGATGAGGCTC
GGAGCTTCTGGCTTCGACGCGGCTTTGTGCCCTCGAACAGCGACCCGATGATGCTGGCTAGGTCGTTGCAGGATATCGCT
GTGTCCGTGAGATCAGGCGCGCGCGCATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11281.89 Da        Isoelectric Point: 7.2091

>AT66068 WP_069693383.1 NZ_CP017147:c1058013-1057714 [Bosea vaviloviae]
MPRAARKDHPLSMRLPEADISIIDRAAKLRGRSRTQFVRDAAVRAAEEAIMEDRPIRMSAEGFAEFVAMLDRPPEVVPAI
AELFRRRAPWEHDESGESR

Download         Length: 300 bp

>AT66068 NZ_CP017147:c1058013-1057714 [Bosea vaviloviae]
ATGCCCCGCGCCGCCCGCAAGGATCATCCGCTTTCGATGCGGCTGCCCGAAGCCGATATCTCGATCATCGACCGGGCGGC
CAAACTGCGCGGGCGGTCGCGAACGCAGTTCGTACGCGACGCGGCGGTTCGCGCGGCGGAAGAGGCGATCATGGAGGATC
GCCCGATCCGGATGAGTGCGGAGGGGTTTGCCGAGTTCGTCGCGATGTTGGACCGTCCCCCCGAGGTCGTACCTGCGATT
GCCGAGCTGTTTCGACGGCGTGCGCCATGGGAACATGATGAATCCGGCGAAAGTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7TXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7U9Z5

References