Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 549934..550471 Replicon chromosome
Accession NZ_CP017147
Organism Bosea vaviloviae strain Vaf18

Toxin (Protein)


Gene name parE Uniprot ID A0A1D7TWL4
Locus tag BHK69_RS02605 Protein ID WP_069688747.1
Coordinates 550169..550471 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1D7TWL8
Locus tag BHK69_RS02600 Protein ID WP_069688746.1
Coordinates 549934..550179 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHK69_RS02570 545837..546394 + 558 WP_069693314.1 HNH endonuclease -
BHK69_RS02575 546480..547694 + 1215 WP_069693315.1 amidohydrolase -
BHK69_RS02580 547719..548243 - 525 WP_069688744.1 disulfide bond formation protein B -
BHK69_RS02585 548254..548865 - 612 WP_069688745.1 DedA family protein -
BHK69_RS02595 549521..549871 - 351 WP_083269082.1 GNAT family N-acetyltransferase -
BHK69_RS02600 549934..550179 + 246 WP_069688746.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BHK69_RS02605 550169..550471 + 303 WP_069688747.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BHK69_RS02610 550675..551035 - 361 Protein_517 type IV secretory system conjugative DNA transfer family protein -
BHK69_RS02615 551155..551898 + 744 WP_069688749.1 aspartate/glutamate racemase family protein -
BHK69_RS02620 551922..552833 - 912 WP_069688750.1 NAD(P)-dependent oxidoreductase -
BHK69_RS02625 552937..554025 + 1089 WP_083269083.1 LacI family DNA-binding transcriptional regulator -
BHK69_RS02630 554034..554936 - 903 WP_069693317.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-95)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11582.06 Da        Isoelectric Point: 6.8788

>T66067 WP_069688747.1 NZ_CP017147:550169-550471 [Bosea vaviloviae]
MSGRRGGYWLSPLAEADLEEIWLYSFREWSADQADKYHNDIVSAFDGIAAGTKKGRPVDIREGYFKYAVGSHVFYYKQVD
TGEIIIIRILHQRMDANRHL

Download         Length: 303 bp

>T66067 NZ_CP017147:550169-550471 [Bosea vaviloviae]
ATGTCCGGTAGGCGCGGTGGGTACTGGCTTTCCCCACTCGCGGAAGCCGATCTTGAAGAAATCTGGCTTTACAGTTTCAG
GGAATGGTCAGCCGATCAGGCGGATAAATACCACAACGATATCGTCTCGGCTTTTGACGGGATCGCGGCGGGCACGAAAA
AGGGCCGTCCCGTCGACATCCGCGAAGGCTACTTCAAATATGCCGTCGGCTCGCATGTCTTCTATTATAAGCAGGTGGAT
ACCGGCGAGATCATCATTATCCGCATCCTCCACCAGCGCATGGACGCCAACCGGCACCTTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9109.19 Da        Isoelectric Point: 6.7263

>AT66067 WP_069688746.1 NZ_CP017147:549934-550179 [Bosea vaviloviae]
MARNTSISLGDHFARFIDTQVEEGRYGSASDVVRAGLRLLEEHEAKVRALQNALIAGEESGAPRPFDNDAFLQKMRERHV
R

Download         Length: 246 bp

>AT66067 NZ_CP017147:549934-550179 [Bosea vaviloviae]
ATGGCCCGCAACACGTCTATTTCCCTTGGCGATCATTTCGCCCGCTTCATTGACACGCAAGTCGAGGAAGGCCGCTACGG
GTCGGCCAGCGATGTCGTGCGCGCAGGATTGCGACTGCTCGAAGAGCATGAGGCCAAGGTCAGGGCGTTGCAAAATGCCC
TAATCGCCGGAGAAGAATCCGGCGCGCCGCGCCCGTTCGACAACGACGCGTTCCTGCAAAAGATGCGGGAACGGCATGTC
CGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7TWL4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7TWL8

References