66065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 10440..11793 Replicon plasmid unnamed1
Accession NZ_CP017144
Organism Aeromonas salmonicida subsp. masoucida strain RFAS1

Toxin (Protein)


Gene name sanaT Uniprot ID A0A807ZF23
Locus tag BHG40_RS22905 Protein ID WP_042468256.1
Coordinates 10440..11405 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag BHG40_RS22910 Protein ID WP_042468273.1
Coordinates 11395..11793 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BHG40_RS22865 6142..6389 + 248 Protein_5 hypothetical protein -
BHG40_RS22870 7152..7463 + 312 WP_042468251.1 helix-turn-helix domain-containing protein -
BHG40_RS22875 7438..8400 + 963 WP_088814090.1 reverse transcriptase family protein -
BHG40_RS22880 8506..8688 - 183 WP_042468252.1 hypothetical protein -
BHG40_RS22885 8853..9005 - 153 WP_042468253.1 Hok/Gef family protein -
BHG40_RS22895 9513..10010 - 498 WP_042468254.1 hypothetical protein -
BHG40_RS22900 10029..10394 - 366 WP_042468255.1 hypothetical protein -
BHG40_RS22905 10440..11405 - 966 WP_042468256.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BHG40_RS22910 11395..11793 - 399 WP_042468273.1 S-adenosylhomocysteine hydrolase Antitoxin
BHG40_RS22915 12730..13176 + 447 WP_042468257.1 DNA repair protein RadC -
BHG40_RS22920 13216..13578 + 363 WP_042468258.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70968 70968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36419.60 Da        Isoelectric Point: 5.4150

>T66065 WP_042468256.1 NZ_CP017144:c11405-10440 [Aeromonas salmonicida subsp. masoucida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I

Download         Length: 966 bp

>T66065 NZ_CP017144:c11405-10440 [Aeromonas salmonicida subsp. masoucida]
ATGCAGCCTAAAGACTCTTCGATTTTCGCCGACGTTTCTGACTACTTCGGGATCGATAACCCTGCGATAGCAGAAAAGGA
CTACTACGTCGTCCAGCTGCTCAAACTGCTTGCAAGTCATTCTTGCCAGCACCACACCATGGTGTTTGCAGGCGGGACCG
CATTAGCCAAAGCTGACGTCAAGCTTCAGCGCATGTCTGAAGATGTCGACATCAAGTTATCTGTTAACGATAGTGCTAAA
GATGAATCTCGAAGCGCGATGAAGCGCCATCGCAAAGCCATCCGAGATGGTTTGATTGAAGAGCTCAATGCGACTGGCGT
TTTCCAAGTAGAGAAGGCTGAGGTCATTTGTCGGGATGAGCACAGGTACATTGAAATGCCGGTGAGATACCCGCAGGCCT
TCAGCAAGGCCCCCTGCCTTCGGCCTTTCATCAAGCTCGAACTCATTGAGACTGATCTGCTTGCAGGCCATAACCCCATG
CCCATTTGTTCGCTGCACAATGAAGCGATGCAGCAAGAACCTGAAGTGCCAGCCTTCAACACGGTTCCCCTGATCTCCAC
CCAAGCCGAGAAAGTGTTGTCGATGCTGCGCAGAACAGCCAGCGTCAAGCATGACCCAGAACGATTGGATGATGAGTCGT
TGGTTCGCCACATTTATGACACTTATCGCCTGCAACAAAGTACCACCTTTGATTTGGCCGAACTGGCAGGGCTGATAGCT
GAAGGGATGAAGATGGATCGTGATCGCTATGGTCCCCAACACCCCGAGTTTGCAGCAGATCCTATCGGTGTGATGCGGTT
TGGCCTGGATGTGATTGCTGGTGACCCCCTATACAAAGATCGTTATGAGGCATTCGTGAAGCCGATGGTGTATGGGGATG
CGTTGACTTGGGATGAGGCATTTCGCGTGTTCGAGGCTGTTGCGCGCCAGGCTCTAGATCACATTGAGCAACACAAACTT
ATTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT66065 WP_042468273.1 NZ_CP017144:c11793-11395 [Aeromonas salmonicida subsp. masoucida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT66065 NZ_CP017144:c11793-11395 [Aeromonas salmonicida subsp. masoucida]
ATGACCATTGCAGACCGTGTTGAAGCACGAATCAAACGATCTAAGCGAGATGTGTTTCTCCGTGAGGATTTCGATGACTT
GGGCGGTTATGACCAAATAGGCAGAGCCTTACGCCAGATGTGTGAAAAGGGTCTGCTTCTGAAGGTCGGCTACGGCGTGT
ATGCAAAGGCACGGCGTAACCGGATCAATAGTCGCTTGATGATCGCCTCCCCTGGAGGTCCAGACGCCGTACTCATTGCT
ACGCTTGACCGCCTGAAGGTGCCTTACGAACTGAAGGGCCTGACCGCAGCTTATGCCGCGGGGAAATCCACTCAGGTTCC
CGCCTTTATGGAAGTTAAGCCTAAAAAGCGTTTTTCCAGAAAGCTGAAAATAGGAAGCCGAGTGTTCAATGCAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZF23

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References