Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 991033..991528 Replicon chromosome
Accession NZ_CP017142
Organism Streptococcus suis strain GZ0565

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8KF86
Locus tag BFP66_RS04980 Protein ID WP_024395851.1
Coordinates 991262..991528 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag BFP66_RS04975 Protein ID WP_015646833.1
Coordinates 991033..991272 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFP66_RS04950 986362..987528 + 1167 WP_024395848.1 ATP-grasp domain-containing protein -
BFP66_RS04955 987668..987808 + 141 WP_032536643.1 hypothetical protein -
BFP66_RS04960 987821..988210 + 390 WP_024395849.1 NisI/SpaI family lantibiotic immunity lipoprotein -
BFP66_RS04965 988219..988971 + 753 WP_015646831.1 ABC transporter ATP-binding protein -
BFP66_RS04970 988972..990942 + 1971 WP_024395850.1 FtsX-like permease family protein -
BFP66_RS04975 991033..991272 + 240 WP_015646833.1 hypothetical protein Antitoxin
BFP66_RS04980 991262..991528 + 267 WP_024395851.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFP66_RS04985 991570..992235 + 666 WP_024395852.1 response regulator transcription factor -
BFP66_RS04990 992232..993173 + 942 Protein_933 sensor histidine kinase -
BFP66_RS04995 993250..994758 + 1509 WP_024395853.1 phosphoglucomutase -
BFP66_RS05000 994821..995891 - 1071 WP_024390379.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10272.03 Da        Isoelectric Point: 10.4518

>T66062 WP_024395851.1 NZ_CP017142:991262-991528 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALIANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T66062 NZ_CP017142:991262-991528 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCCGCTAAGGCTCAAAAGCAAATTCGAAAGATGGATAAAACTGCTGCAAGTTTGATTTT
GCGGTATCTTTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGATTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT66062 WP_015646833.1 NZ_CP017142:991033-991272 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT66062 NZ_CP017142:991033-991272 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGATAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCGCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8KF86

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References