Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 2153911..2154425 | Replicon | chromosome |
Accession | NZ_CP017115 | ||
Organism | Staphylococcus aureus strain FORC_045 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | A0A641A3V2 |
Locus tag | FORC45_RS11195 | Protein ID | WP_000581793.1 |
Coordinates | 2153911..2154120 (-) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | W8UW13 |
Locus tag | FORC45_RS11200 | Protein ID | WP_000138932.1 |
Coordinates | 2154132..2154425 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FORC45_RS11175 | 2149420..2150778 | - | 1359 | WP_000611483.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
FORC45_RS11180 | 2150793..2151863 | - | 1071 | WP_000159627.1 | D-alanine--D-alanine ligase | - |
FORC45_RS11185 | 2152181..2153383 | + | 1203 | WP_001109939.1 | rod shape-determining protein RodA | - |
FORC45_RS11190 | 2153646..2153783 | - | 138 | WP_000828354.1 | hypothetical protein | - |
FORC45_RS11195 | 2153911..2154120 | - | 210 | WP_000581793.1 | heavy-metal-associated domain-containing protein | Toxin |
FORC45_RS11200 | 2154132..2154425 | - | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
FORC45_RS11205 | 2154591..2156075 | + | 1485 | WP_000571549.1 | cardiolipin synthase | - |
FORC45_RS11210 | 2156103..2156750 | + | 648 | WP_001187628.1 | HD domain-containing protein | - |
FORC45_RS11225 | 2157364..2158236 | - | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
FORC45_RS11230 | 2158322..2158963 | - | 642 | WP_000483155.1 | thiamine phosphate synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7809.75 Da Isoelectric Point: 4.1008
>T66043 WP_000581793.1 NZ_CP017115:c2154120-2153911 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI
Download Length: 210 bp
>T66043 NZ_CP017115:c2154120-2153911 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT66043 WP_000138932.1 NZ_CP017115:c2154425-2154132 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT66043 NZ_CP017115:c2154425-2154132 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A641A3V2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | W8UW13 |