Detailed information of TA system TA066034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 850921..851398
• Replicon: chromosome
• Accession: NZ_CP017115
• Organism: Staphylococcus aureus strain FORC_045

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: FORC45_RS04270
• Protein ID: WP_000052076.1
• Coordinates: 850921..851109 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: FORC45_RS04275
• Protein ID: WP_001837253.1
• Coordinates: 851138..851398 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC45_RS04240	846911..847432	+	522	WP_000824464.1	hypothetical protein	-
FORC45_RS04245	847773..848459	+	687	WP_001793574.1	thermonuclease family protein	-
FORC45_RS04250	848816..849016	+	201	WP_001059082.1	cold-shock protein	-
FORC45_RS04255	849512..849730	-	219	WP_000005886.1	hypothetical protein	-
FORC45_RS04260	849792..850076	-	285	WP_001004401.1	hypothetical protein	-
FORC45_RS04265	850164..850733	-	570	WP_001106654.1	hypothetical protein	-
FORC45_RS04270	850921..851109	-	189	WP_000052076.1	hypothetical protein	Toxin
FORC45_RS04275	851138..851398	-	261	WP_001837253.1	hypothetical protein	Antitoxin
FORC45_RS04280	851738..851941	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
FORC45_RS04285	851938..852174	-	237	WP_000368687.1	hypothetical protein	-
FORC45_RS04290	852398..852979	+	582	WP_001140696.1	phosphoglycerate mutase family protein	-
FORC45_RS04295	853028..853645	-	618	WP_000255544.1	LysE/ArgO family amino acid transporter	-
FORC45_RS04300	853800..854294	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
FORC45_RS04305	854693..855115	-	423	WP_000974464.1	organic hydroperoxide resistance protein	-
FORC45_RS04310	855263..855979	+	717	WP_000150012.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T66034 WP_000052076.1 NZ_CP017115:c851109-850921 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T66034 NZ_CP017115:c851109-850921 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9928.03 Da
• Isoelectric Point: 4.0624

>AT66034 WP_001837253.1 NZ_CP017115:c851398-851138 [Staphylococcus aureus]
MNNILLNAINTVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT66034 NZ_CP017115:c851398-851138 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATACAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18