Detailed information of TA system TA066016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2567545..2568013
• Replicon: chromosome
• Accession: NZ_CP017111
• Organism: Sulfurospirillum halorespirans DSM 13726 strain PCE-M2

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: SHALO_RS12905
• Protein ID: WP_202968803.1
• Coordinates: 2567744..2568013 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1D7TMW2
• Locus tag: SHALO_RS12900
• Protein ID: WP_069478874.1
• Coordinates: 2567545..2567760 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHALO_RS12880	2562639..2564036	+	1398	WP_069478871.1	HAMP domain-containing histidine kinase	-
SHALO_RS12885	2564097..2565653	+	1557	WP_084010940.1	phosphoethanolamine--lipid A transferase	-
SHALO_RS12890	2565699..2566172	+	474	WP_069478872.1	DNA-deoxyinosine glycosylase	-
SHALO_RS12895	2566248..2567435	+	1188	WP_069478873.1	EAL domain-containing protein	-
SHALO_RS12900	2567545..2567760	+	216	WP_069478874.1	hypothetical protein	Antitoxin
SHALO_RS12905	2567744..2568013	+	270	WP_202968803.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SHALO_RS12910	2568048..2569577	-	1530	WP_069478876.1	PAS domain S-box protein	-
SHALO_RS12915	2569567..2571258	-	1692	WP_069478877.1	PAS domain-containing sensor histidine kinase	-
SHALO_RS12920	2571267..2571635	-	369	WP_025345874.1	response regulator	-
SHALO_RS12925	2571639..2572961	-	1323	WP_069478878.1	CZB domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10616.55 Da
• Isoelectric Point: 10.4451

>T66016 WP_202968803.1 NZ_CP017111:2567744-2568013 [Sulfurospirillum halorespirans DSM 13726]
MAWIVKFKESAKKELSKLDKPIAKKLVIFLQQLSNCDDPRHKGKQLKGKLKDFWRYRVSDYRIITKITDQEITILVLKVA
HRKDVYEDQ

Nucleotide

• Length: 270 bp

>T66016 NZ_CP017111:2567744-2568013 [Sulfurospirillum halorespirans DSM 13726]
TTGGCTTGGATCGTTAAATTTAAAGAGAGTGCCAAAAAAGAGCTTTCAAAACTAGACAAACCTATTGCAAAAAAGCTTGT
TATCTTTTTACAACAACTAAGTAATTGTGATGATCCTAGGCATAAAGGTAAACAGCTCAAGGGTAAACTCAAAGATTTTT
GGAGATATAGAGTGAGTGATTATCGCATCATTACCAAAATCACCGATCAAGAAATCACTATTTTAGTTTTAAAAGTGGCA
CATCGTAAAGATGTTTACGAGGATCAATAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8412.38 Da
• Isoelectric Point: 4.1357

>AT66016 WP_069478874.1 NZ_CP017111:2567545-2567760 [Sulfurospirillum halorespirans DSM 13726]
MATSIRLDDSFEARLSRLASLTDRPKSFYIRKLFEDYFENLEDYYLAEKADQTPEPIYTLDEVVQELGLDR

Nucleotide

• Length: 216 bp

>AT66016 NZ_CP017111:2567545-2567760 [Sulfurospirillum halorespirans DSM 13726]
ATGGCGACTTCCATTCGACTTGATGATAGTTTTGAAGCACGCTTAAGCCGTTTAGCCTCATTAACCGATCGTCCAAAATC
TTTTTATATCCGCAAATTATTTGAGGATTATTTTGAAAATTTGGAAGATTATTATTTGGCAGAAAAAGCAGATCAAACGC
CTGAGCCAATTTATACCTTAGATGAAGTGGTACAAGAACTTGGCTTGGATCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1D7TMW2