Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 1277052..1277922 Replicon plasmid pRgalIE4872d
Accession NZ_CP017105
Organism Rhizobium gallicum strain IE4872

Toxin (Protein)


Gene name - Uniprot ID A0A1L5NV23
Locus tag IE4872_RS31155 Protein ID WP_074072034.1
Coordinates 1277052..1277558 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1L5NV54
Locus tag IE4872_RS31160 Protein ID WP_074072035.1
Coordinates 1277551..1277922 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4872_RS31145 1273483..1274922 + 1440 WP_156886604.1 FAD/NAD(P)-binding protein -
IE4872_RS31150 1275231..1276727 + 1497 WP_074073085.1 DegQ family serine endoprotease -
IE4872_RS31155 1277052..1277558 - 507 WP_074072034.1 RES domain-containing protein Toxin
IE4872_RS31160 1277551..1277922 - 372 WP_074072035.1 DUF2384 domain-containing protein Antitoxin
IE4872_RS31165 1277984..1278775 - 792 WP_074072036.1 crotonase/enoyl-CoA hydratase family protein -
IE4872_RS31170 1278772..1279641 - 870 WP_074073086.1 hydroxymethylglutaryl-CoA lyase -
IE4872_RS31175 1279641..1281620 - 1980 WP_074072038.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / katA / htpB 1..2388366 2388366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(8-161)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18828.71 Da        Isoelectric Point: 7.4152

>T66008 WP_074072034.1 NZ_CP017105:c1277558-1277052 [Rhizobium gallicum]
MPETVVHLWCAFVPRWAHAPLSGEGASRFGGRWNPMGAPTIYAACELSTAWAEYNQGFVQHPAMVVQLELKGARLADTTD
QMLLRKFDVTADIHRCEWRMLMDGSKVPATHHLRERLIASRYHGAIYPSFMSLGGTCVALWEWNMPGAPELRAIDPEGRL
PKSPASWL

Download         Length: 507 bp

>T66008 NZ_CP017105:c1277558-1277052 [Rhizobium gallicum]
ATGCCTGAGACCGTCGTGCATCTATGGTGCGCCTTCGTTCCACGATGGGCCCATGCGCCGCTTTCTGGCGAGGGCGCCAG
CCGTTTTGGTGGCCGGTGGAATCCGATGGGTGCCCCGACCATCTATGCGGCCTGCGAGCTGTCCACGGCCTGGGCCGAAT
ATAACCAGGGCTTTGTTCAGCACCCGGCGATGGTCGTGCAATTGGAACTCAAAGGGGCGCGCCTCGCGGACACGACCGAC
CAGATGCTTCTTCGAAAGTTTGACGTTACTGCGGATATCCATCGTTGCGAATGGCGGATGCTGATGGATGGAAGCAAGGT
GCCGGCAACCCACCACCTGCGCGAACGTCTGATTGCATCGCGATATCATGGCGCGATCTATCCATCTTTCATGTCGCTTG
GCGGCACATGCGTCGCGCTGTGGGAATGGAATATGCCGGGTGCACCGGAGCTTCGCGCAATCGATCCAGAGGGTCGACTG
CCCAAATCACCGGCCTCCTGGTTGTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13057.91 Da        Isoelectric Point: 10.1453

>AT66008 WP_074072035.1 NZ_CP017105:c1277922-1277551 [Rhizobium gallicum]
MAATGLSNVAARFGDEHSSFLSARRVAEQLGVTLSELARLIGVARNTLAAKSGARKVDNALSNVVRILAMASEMAGDENR
AVIWFKHQPIPGWGGKTAFDLVGEGKSDRVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT66008 NZ_CP017105:c1277922-1277551 [Rhizobium gallicum]
ATGGCAGCTACAGGCCTCAGCAATGTCGCTGCTCGCTTCGGCGATGAACATTCGTCGTTTCTATCGGCCCGGCGCGTCGC
CGAGCAACTGGGCGTAACGCTCTCCGAGCTAGCCCGGCTGATCGGGGTTGCGCGCAATACGCTGGCGGCGAAATCGGGCG
CCCGCAAAGTGGATAATGCGCTGAGCAACGTCGTCCGCATCCTTGCGATGGCAAGCGAAATGGCCGGCGACGAAAACCGT
GCGGTCATATGGTTCAAGCATCAGCCGATCCCCGGTTGGGGCGGCAAGACGGCGTTTGACCTTGTCGGCGAAGGCAAGTC
CGACCGGGTTCTCGCCTATCTCGAGGCCGTCCGCTCCGGCGTCTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5NV23

Antitoxin

Source ID Structure
AlphaFold DB A0A1L5NV54

References