Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3408666..3409300 Replicon chromosome
Accession NZ_CP017101
Organism Rhizobium gallicum strain IE4872

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L5NM38
Locus tag IE4872_RS17225 Protein ID WP_074069504.1
Coordinates 3408666..3409055 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L5NM64
Locus tag IE4872_RS17230 Protein ID WP_074069505.1
Coordinates 3409052..3409300 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4872_RS17195 3403905..3404921 + 1017 WP_074069500.1 amino acid ABC transporter substrate-binding protein -
IE4872_RS17200 3404935..3406086 + 1152 WP_074069501.1 ABC transporter permease subunit -
IE4872_RS17205 3406083..3407183 + 1101 WP_074069502.1 amino acid ABC transporter permease -
IE4872_RS17210 3407180..3407926 + 747 WP_074069503.1 amino acid ABC transporter ATP-binding protein -
IE4872_RS17215 3407985..3408224 - 240 Protein_3330 SDR family NAD(P)-dependent oxidoreductase -
IE4872_RS17220 3408179..3408622 - 444 Protein_3331 hydantoinase B/oxoprolinase family protein -
IE4872_RS17225 3408666..3409055 - 390 WP_074069504.1 type II toxin-antitoxin system VapC family toxin Toxin
IE4872_RS17230 3409052..3409300 - 249 WP_074069505.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IE4872_RS17235 3409945..3411111 + 1167 WP_074070398.1 efflux RND transporter periplasmic adaptor subunit -
IE4872_RS17240 3411108..3414170 + 3063 WP_074069506.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14261.27 Da        Isoelectric Point: 4.9047

>T66006 WP_074069504.1 NZ_CP017101:c3409055-3408666 [Rhizobium gallicum]
MIMDTSAMVAILYGEPEAAAFTRLIHDSATSRISVANYVELSMVIEKQLGPEGMRQADAFFRRAVIDIEPVTVEQGHLAR
QAFLDFGKGRHKAGLNFGDCFAYALARDFGEPLLFKGNDFTETDIRSAI

Download         Length: 390 bp

>T66006 NZ_CP017101:c3409055-3408666 [Rhizobium gallicum]
ATGATTATGGATACATCCGCCATGGTGGCGATCCTCTACGGCGAGCCAGAGGCTGCCGCCTTCACGCGACTGATCCACGA
TTCCGCAACCAGCCGGATCAGCGTGGCGAACTATGTGGAACTGTCCATGGTGATCGAAAAGCAGCTCGGGCCGGAAGGCA
TGAGGCAGGCCGATGCCTTCTTCCGTCGCGCAGTGATCGACATCGAGCCCGTGACCGTTGAGCAGGGGCATCTGGCCCGA
CAGGCATTCCTTGATTTCGGGAAGGGCAGGCACAAAGCTGGACTGAATTTCGGCGACTGCTTTGCCTACGCTCTCGCCAG
GGATTTCGGCGAACCGTTGCTGTTCAAGGGCAACGATTTCACCGAGACGGACATCCGTTCGGCCATATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 6.8797

>AT66006 WP_074069505.1 NZ_CP017101:c3409300-3409052 [Rhizobium gallicum]
MSLNVKDPEAHRLAQAIAHATGQSMSRVVTDALRERYAQIEKQRGRASFEELLAIADRAAVHLKRPYADHAELLYDEDGL
PK

Download         Length: 249 bp

>AT66006 NZ_CP017101:c3409300-3409052 [Rhizobium gallicum]
ATGAGCCTCAACGTGAAAGACCCCGAAGCGCATCGCCTCGCCCAGGCGATCGCCCATGCGACCGGGCAGAGCATGAGCCG
CGTCGTGACCGACGCTCTGCGTGAGCGGTATGCGCAAATTGAAAAACAGAGAGGTAGGGCCTCGTTCGAAGAACTTCTGG
CGATCGCCGACAGGGCCGCAGTCCATTTGAAGCGGCCTTATGCTGACCACGCCGAGCTTCTTTATGACGAGGACGGCCTG
CCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5NM38

Antitoxin

Source ID Structure
AlphaFold DB A0A1L5NM64

References