Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HEPN-MNT
Location 3301651..3302468 Replicon chromosome
Accession NC_004347
Organism Shewanella oneidensis MR-1

Toxin (Protein)


Gene name hepT Uniprot ID Q8ECH6
Locus tag SO_RS14755 Protein ID WP_011073053.1
Coordinates 3302072..3302473 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID Q8ECH7
Locus tag SO_RS14750 Protein ID WP_011073052.1
Coordinates 3301656..3302075 (+) Length 140 a.a.

Genomic Context

SO_RS14740SO_RS14745SO_RS14750SO_RS14755SO_RS14725SO_RS14730SO_RS14735SO_RS14760SO_RS14765SO_RS14770SO_RS14775
Location: 3300043..3300489 (447 bp)
Type: Others
Protein ID: WP_164925739.1
Location: 3300783..3301550 (768 bp)
Type: Others
Protein ID: WP_011073051.1
Location: 3301656..3302075 (420 bp)
Type: Antitoxin
Protein ID: WP_011073052.1
Location: 3302072..3302473 (402 bp)
Type: Toxin
Protein ID: WP_011073053.1
Location: 3297552..3298091 (540 bp)
Type: Others
Protein ID: WP_011073048.1
Location: 3298078..3298260 (183 bp)
Type: Others
Protein ID: Protein_2853
Location: 3298465..3299826 (1362 bp)
Type: Others
Protein ID: WP_011073049.1
Location: 3302667..3303698 (1032 bp)
Type: Others
Protein ID: WP_011073054.1
Location: 3303962..3305161 (1200 bp)
Type: Others
Protein ID: WP_164925891.1
Location: 3305365..3305757 (393 bp)
Type: Others
Protein ID: WP_164925740.1
Location: 3305742..3307109 (1368 bp)
Type: Others
Protein ID: WP_011073057.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SO_RS14725 (SO_3160)3297552..3298091-540WP_011073048.1dTDP-4-dehydrorhamnose 3,5-epimerase-
SO_RS14730 (SO_3161)3298078..3298260-183Protein_2853glucose-1-phosphate thymidylyltransferase-
SO_RS14735 (SO_3162)3298465..3299826-1362WP_011073049.1GAF domain-containing sensor histidine kinase-
SO_RS14740 (SO_3163)3300043..3300489+447WP_164925739.1copper resistance protein NlpE-
SO_RS14745 (SO_3164)3300783..3301550+768WP_011073051.1HutD family protein-
SO_RS14750 (SO_3165)3301656..3302075+420WP_011073052.1type II toxin-antitoxin system antitoxinAntitoxin
SO_RS14755 (SO_3166)3302072..3302473+402WP_011073053.1type II toxin-antitoxin system toxinToxin
SO_RS14760 (SO_3167)3302667..3303698-1032WP_011073054.1dTDP-glucose 4,6-dehydratase-
SO_RS14765 (SO_3168)3303962..3305161-1200WP_164925891.1molecular chaperone DnaJ-
SO_RS14770 (SO_3169)3305365..3305757-393WP_164925740.1helix-turn-helix domain-containing protein-
SO_RS14775 (SO_3170)3305742..3307109-1368WP_011073057.1HipA domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15312.57 Da        Isoelectric Point: 6.3185

>T660 WP_011073053.1 NC_004347:3302072-3302473 [Shewanella oneidensis MR-1]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLSDNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

>T660 NC_004347:3302072-3302473 [Shewanella oneidensis MR-1]
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGCAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCTCGGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGCAGTACATGACTACCAAGAACT
CAACCTCGATATCGTTGTGCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15566.64 Da        Isoelectric Point: 4.8616

>AT660 WP_011073052.1 NC_004347:3301656-3302075 [Shewanella oneidensis MR-1]
MQQLNENKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKAHRGESL

Download         Length: 420 bp

>AT660 NC_004347:3301656-3302075 [Shewanella oneidensis MR-1]
ATGCAACAACTAAATGAAAATAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACC
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGCTC
ATAGGGGGGAGTCACTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6M6U
PDB6M6W
PDB7AER
PDB7BXO
PDB6M6V
PDB5YEP

Antitoxin

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Source
ID
Structure
PDB6M6U
PDB6M6W
PDB7AER
PDB7BXO
PDB6M6V
PDB5YEP
AlphaFold DBQ8ECH7

References

(1) Jianyun Yao et al. (2015) Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis. Microbial Biotechnology 8(6):961-73. [PubMed:26112399] experimental

(2) Xuanyan Jia et al. (2018) Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system. The Journal of Biological Chemistry 293(18):6812-6823. [PubMed:29555683] 3D_structure

(3) Jianyun Yao et al. (2020) Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Research 48(19):11054-11067. [PubMed:33045733] 3D_structure


experimental experimental literature
3D_structure protein structure literature