Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1188203..1188680 Replicon chromosome
Accession NZ_CP017094
Organism Staphylococcus aureus strain 2148.C01

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag A7U45_RS06285 Protein ID WP_000052078.1
Coordinates 1188492..1188680 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7U45_RS06280 Protein ID WP_001059690.1
Coordinates 1188203..1188463 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U45_RS06245 1183596..1184312 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
A7U45_RS06250 1184460..1184882 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
A7U45_RS06255 1185281..1185775 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
A7U45_RS06260 1185930..1186547 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A7U45_RS06265 1186620..1187201 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
A7U45_RS06270 1187426..1187662 + 237 WP_000368687.1 hypothetical protein -
A7U45_RS06275 1187659..1187862 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7U45_RS06280 1188203..1188463 + 261 WP_001059690.1 hypothetical protein Antitoxin
A7U45_RS06285 1188492..1188680 + 189 WP_000052078.1 hypothetical protein Toxin
A7U45_RS06290 1188868..1189437 + 570 WP_001106654.1 hypothetical protein -
A7U45_RS06295 1189525..1189809 + 285 WP_001004395.1 hypothetical protein -
A7U45_RS06300 1189871..1190089 + 219 WP_000005886.1 hypothetical protein -
A7U45_RS06305 1190585..1190785 - 201 WP_001059082.1 cold-shock protein -
A7U45_RS06310 1191142..1191828 - 687 WP_001548082.1 thermonuclease family protein -
A7U45_RS06315 1192169..1192639 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T65941 WP_000052078.1 NZ_CP017094:1188492-1188680 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65941 NZ_CP017094:1188492-1188680 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65941 WP_001059690.1 NZ_CP017094:1188203-1188463 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65941 NZ_CP017094:1188203-1188463 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References