Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2168476..2168990 Replicon chromosome
Accession NZ_CP017091
Organism Staphylococcus aureus strain ISU926 isolate ST398

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag A2U18_RS11185 Protein ID WP_000581792.1
Coordinates 2168476..2168685 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag A2U18_RS11190 Protein ID WP_000138932.1
Coordinates 2168697..2168990 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U18_RS11165 2163987..2165342 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
A2U18_RS11170 2165357..2166427 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
A2U18_RS11175 2166745..2167947 + 1203 WP_001109939.1 rod shape-determining protein RodA -
A2U18_RS11180 2168211..2168348 - 138 WP_000828354.1 hypothetical protein -
A2U18_RS11185 2168476..2168685 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
A2U18_RS11190 2168697..2168990 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
A2U18_RS11195 2169156..2170640 + 1485 WP_000571550.1 cardiolipin synthase -
A2U18_RS11200 2170668..2171315 + 648 WP_001187614.1 HD domain-containing protein -
A2U18_RS11205 2171595..2171915 + 321 WP_001825748.1 hypothetical protein -
A2U18_RS11210 2171912..2173227 - 1316 Protein_2062 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T65933 WP_000581792.1 NZ_CP017091:c2168685-2168476 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T65933 NZ_CP017091:c2168685-2168476 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT65933 WP_000138932.1 NZ_CP017091:c2168990-2168697 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT65933 NZ_CP017091:c2168990-2168697 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References