Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1585544..1586347 Replicon chromosome
Accession NZ_CP017091
Organism Staphylococcus aureus strain ISU926 isolate ST398

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag A2U18_RS07930 Protein ID WP_088445687.1
Coordinates 1585886..1586347 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag A2U18_RS07925 Protein ID WP_071938164.1
Coordinates 1585544..1585873 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U18_RS07860 1581525..1581887 - 363 WP_071938163.1 hypothetical protein -
A2U18_RS07865 1581902..1582225 - 324 WP_000174994.1 hypothetical protein -
A2U18_RS07870 1582304..1582465 - 162 WP_001285955.1 DUF1270 family protein -
A2U18_RS07875 1582478..1582741 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
A2U18_RS07880 1582766..1582981 - 216 WP_001097552.1 hypothetical protein -
A2U18_RS07885 1583036..1583401 + 366 WP_001128433.1 hypothetical protein -
A2U18_RS07890 1583370..1583615 - 246 WP_001025401.1 DUF2829 domain-containing protein -
A2U18_RS07895 1583682..1584062 + 381 WP_000773059.1 DUF2513 domain-containing protein -
A2U18_RS07900 1584049..1584246 - 198 WP_001148860.1 hypothetical protein -
A2U18_RS07905 1584316..1584528 + 213 WP_000362644.1 hypothetical protein -
A2U18_RS14730 1584569..1584718 - 150 WP_000771849.1 hypothetical protein -
A2U18_RS07910 1584774..1584983 + 210 WP_000642492.1 hypothetical protein -
A2U18_RS07915 1584973..1585116 - 144 WP_000939498.1 hypothetical protein -
A2U18_RS07920 1585132..1585380 - 249 WP_000272860.1 helix-turn-helix domain-containing protein -
A2U18_RS07925 1585544..1585873 + 330 WP_071938164.1 helix-turn-helix domain-containing protein Antitoxin
A2U18_RS07930 1585886..1586347 + 462 WP_088445687.1 toxin Toxin
A2U18_RS07935 1586365..1586949 + 585 WP_000825948.1 hypothetical protein -
A2U18_RS07940 1587179..1587325 + 147 WP_078099401.1 hypothetical protein -
A2U18_RS07945 1587322..1587936 - 615 WP_000191458.1 hypothetical protein -
A2U18_RS07950 1588062..1589267 + 1206 WP_000264747.1 site-specific integrase -
A2U18_RS07955 1589310..1591337 - 2028 WP_016187433.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1542134..1602023 59889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18014.42 Da        Isoelectric Point: 4.6914

>T65930 WP_088445687.1 NZ_CP017091:1585886-1586347 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSECLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T65930 NZ_CP017091:1585886-1586347 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTGTCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12657.28 Da        Isoelectric Point: 7.2034

>AT65930 WP_071938164.1 NZ_CP017091:1585544-1585873 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENDDEVQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT65930 NZ_CP017091:1585544-1585873 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGATGATGAAGTACAACAT
CGTGCAGCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAA
ACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References