Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 858852..859328 Replicon chromosome
Accession NZ_CP017091
Organism Staphylococcus aureus strain ISU926 isolate ST398

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag A2U18_RS04250 Protein ID WP_000052076.1
Coordinates 858852..859040 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A2U18_RS04255 Protein ID WP_001059690.1
Coordinates 859068..859328 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U18_RS04220 854881..855363 + 483 WP_000824489.1 hypothetical protein -
A2U18_RS04225 855704..856390 + 687 WP_001574556.1 thermonuclease family protein -
A2U18_RS04230 856747..856947 + 201 WP_001059082.1 cold-shock protein -
A2U18_RS04235 857444..857662 - 219 WP_000005881.1 hypothetical protein -
A2U18_RS04240 857723..858007 - 285 WP_001004403.1 hypothetical protein -
A2U18_RS04245 858095..858664 - 570 WP_001106655.1 hypothetical protein -
A2U18_RS04250 858852..859040 - 189 WP_000052076.1 hypothetical protein Toxin
A2U18_RS04255 859068..859328 - 261 WP_001059690.1 hypothetical protein Antitoxin
A2U18_RS04260 859670..859873 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A2U18_RS04265 859870..860106 - 237 WP_000368687.1 hypothetical protein -
A2U18_RS04270 860331..860912 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
A2U18_RS04275 860985..861602 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
A2U18_RS04280 861751..862245 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
A2U18_RS04285 862644..863066 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
A2U18_RS04290 863214..863930 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T65925 WP_000052076.1 NZ_CP017091:c859040-858852 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65925 NZ_CP017091:c859040-858852 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65925 WP_001059690.1 NZ_CP017091:c859328-859068 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65925 NZ_CP017091:c859328-859068 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References