65911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 863494..863971 Replicon chromosome
Accession NZ_CP017090
Organism Staphylococcus aureus strain ISU935 isolate ST5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag A2V17_RS04265 Protein ID WP_000052076.1
Coordinates 863494..863682 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A2V17_RS04270 Protein ID WP_001059690.1
Coordinates 863711..863971 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2V17_RS04235 859489..860010 + 522 WP_000824482.1 hypothetical protein -
A2V17_RS04240 860351..861037 + 687 WP_000141557.1 thermonuclease family protein -
A2V17_RS04245 861394..861594 + 201 WP_001059082.1 cold-shock protein -
A2V17_RS04250 862085..862303 - 219 WP_000005886.1 hypothetical protein -
A2V17_RS04255 862365..862649 - 285 WP_001004399.1 hypothetical protein -
A2V17_RS04260 862737..863306 - 570 WP_001106654.1 hypothetical protein -
A2V17_RS04265 863494..863682 - 189 WP_000052076.1 hypothetical protein Toxin
A2V17_RS04270 863711..863971 - 261 WP_001059690.1 hypothetical protein Antitoxin
A2V17_RS04275 864312..864515 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A2V17_RS04280 864512..864748 - 237 WP_000349581.1 hypothetical protein -
A2V17_RS04285 864973..865554 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
A2V17_RS04290 865627..866244 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
A2V17_RS04295 866399..866893 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
A2V17_RS04300 867292..867714 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
A2V17_RS04305 867862..868578 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T65911 WP_000052076.1 NZ_CP017090:c863682-863494 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65911 NZ_CP017090:c863682-863494 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65911 WP_001059690.1 NZ_CP017090:c863971-863711 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65911 NZ_CP017090:c863971-863711 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References