Detailed information of TA system TA065909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1020202..1020697
• Replicon: chromosome
• Accession: NZ_CP017088
• Organism: Streptococcus suis strain SRD478

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A7J08_RS05150
• Protein ID: WP_105139425.1
• Coordinates: 1020431..1020697 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A123SEG2
• Locus tag: A7J08_RS05145
• Protein ID: WP_015646833.1
• Coordinates: 1020202..1020441 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7J08_RS05125	1015689..1016555	+	867	Protein_942	helix-turn-helix transcriptional regulator	-
A7J08_RS05130	1016955..1017251	+	297	WP_148115762.1	lactococcin 972 family bacteriocin	-
A7J08_RS05135	1017409..1019427	+	2019	Protein_944	bacteriocin-associated integral membrane family protein	-
A7J08_RS05140	1019429..1020058	+	630	WP_105148459.1	ABC transporter ATP-binding protein	-
A7J08_RS05145	1020202..1020441	+	240	WP_015646833.1	hypothetical protein	Antitoxin
A7J08_RS05150	1020431..1020697	+	267	WP_105139425.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7J08_RS05155	1020736..1021404	+	669	WP_172064090.1	response regulator transcription factor	-
A7J08_RS05160	1021401..1022342	+	942	WP_148115763.1	sensor histidine kinase	-
A7J08_RS05165	1022417..1023925	+	1509	WP_053867315.1	phosphoglucomutase	-
A7J08_RS05170	1023995..1025065	-	1071	WP_024397884.1	tyrosine recombinase XerS	-
A7J08_RS05175	1025232..1025573	-	342	Protein_952	adenylyl-sulfate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10201.94 Da
• Isoelectric Point: 10.5679

>T65909 WP_105139425.1 NZ_CP017088:1020431-1020697 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEGDKLIVTALEV
GHRKEIYK

Nucleotide

• Length: 267 bp

>T65909 NZ_CP017088:1020431-1020697 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGGTGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8879.09 Da
• Isoelectric Point: 3.7832

>AT65909 WP_015646833.1 NZ_CP017088:1020202-1020441 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT65909 NZ_CP017088:1020202-1020441 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAGGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAAACACTTGAAGCCCTTGAAGATGAATACGATGCGCGTGTGGCAGATATAGCCTGGGCAG
AATACCAAGAAGACTTGGCAAACGGCATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A123SEG2