Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4013310..4013930 Replicon chromosome
Accession NZ_CP017087
Organism Enterobacter sp. HK169

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag EnteroDNA1_RS19045 Protein ID WP_008499287.1
Coordinates 4013310..4013528 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag EnteroDNA1_RS19050 Protein ID WP_008499288.1
Coordinates 4013556..4013930 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EnteroDNA1_RS19015 4009324..4009584 + 261 WP_047061249.1 type B 50S ribosomal protein L31 -
EnteroDNA1_RS19020 4009587..4009727 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EnteroDNA1_RS19025 4009724..4010434 - 711 WP_048975521.1 GNAT family N-acetyltransferase -
EnteroDNA1_RS19030 4010536..4011996 + 1461 WP_069303749.1 PLP-dependent aminotransferase family protein -
EnteroDNA1_RS19035 4011968..4012435 - 468 WP_023310598.1 hypothetical protein -
EnteroDNA1_RS19040 4012553..4013104 - 552 WP_047061252.1 maltose O-acetyltransferase -
EnteroDNA1_RS19045 4013310..4013528 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
EnteroDNA1_RS19050 4013556..4013930 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
EnteroDNA1_RS19055 4014442..4017588 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit -
EnteroDNA1_RS19060 4017611..4018804 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T65908 WP_008499287.1 NZ_CP017087:c4013528-4013310 [Enterobacter sp. HK169]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T65908 NZ_CP017087:c4013528-4013310 [Enterobacter sp. HK169]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGATACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT65908 WP_008499288.1 NZ_CP017087:c4013930-4013556 [Enterobacter sp. HK169]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT65908 NZ_CP017087:c4013930-4013556 [Enterobacter sp. HK169]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACATCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCGCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References