Detailed information of TA system TA065907

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3493208..3493885
• Replicon: chromosome
• Accession: NZ_CP017087
• Organism: Enterobacter sp. HK169

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: EnteroDNA1_RS16605
• Protein ID: WP_069303595.1
• Coordinates: 3493565..3493885 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: EnteroDNA1_RS16600
• Protein ID: WP_069303594.1
• Coordinates: 3493208..3493531 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EnteroDNA1_RS16565	3489010..3489738	+	729	WP_069303588.1	DUF3944 domain-containing protein	-
EnteroDNA1_RS16570	3489798..3490475	+	678	WP_069303589.1	WYL domain-containing protein	-
EnteroDNA1_RS16575	3490530..3490994	+	465	WP_069303590.1	hypothetical protein	-
EnteroDNA1_RS16580	3491081..3491440	+	360	WP_069303591.1	hypothetical protein	-
EnteroDNA1_RS16585	3491522..3491734	+	213	WP_049141565.1	hypothetical protein	-
EnteroDNA1_RS16590	3491833..3492654	+	822	WP_069303592.1	DUF945 domain-containing protein	-
EnteroDNA1_RS16595	3492725..3493195	+	471	WP_069303593.1	DNA repair protein RadC	-
EnteroDNA1_RS16600	3493208..3493531	+	324	WP_069303594.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EnteroDNA1_RS16605	3493565..3493885	+	321	WP_069303595.1	TA system toxin CbtA family protein	Toxin
EnteroDNA1_RS16610	3493999..3494829	+	831	WP_069303596.1	DUF4942 domain-containing protein	-
EnteroDNA1_RS16615	3494906..3495913	+	1008	WP_017880110.1	restriction endonuclease	-
EnteroDNA1_RS16620	3496094..3496963	-	870	WP_069303597.1	HNH endonuclease	-
EnteroDNA1_RS22205	3497264..3497737	+	474	WP_073001057.1	SymE family type I addiction module toxin	-
EnteroDNA1_RS16630	3497817..3498188	-	372	WP_029739309.1	hypothetical protein	-
EnteroDNA1_RS16635	3498304..3498783	-	480	WP_069303598.1	type VI secretion system tube protein Hcp	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3470878..3499809	28931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12077.65 Da
• Isoelectric Point: 5.0356

>T65907 WP_069303595.1 NZ_CP017087:3493565-3493885 [Enterobacter sp. HK169]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFQDDEAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQDQTPFLTATDILRARRATGLINT

Nucleotide

• Length: 321 bp

>T65907 NZ_CP017087:3493565-3493885 [Enterobacter sp. HK169]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAACACCATTACGGCCTGACACTTAACGACACGCCATTTCAAGACGACGAGGCCATCCAAGAGCATATTG
AAGCTGGTATTACACTTGCTGATGCAGTGAATTTCCTAGTGGAACGCTATGAACTGGTACGCACTGACCGTAAGGGATTC
ACTTGGCAAGATCAAACACCATTCCTGACCGCCACCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATAAATACTTG
A

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12050.63 Da
• Isoelectric Point: 5.5842

>AT65907 WP_069303594.1 NZ_CP017087:3493208-3493531 [Enterobacter sp. HK169]
MPFTLSHGWGIQSDITQRFGARLVQEGNRLHYLADRASLTGSFSPEQLQSLENAFPLFIEQLGNMLRSGELNPQQQRQMT
IQLTGLTCIADTLSSWGYVYLTVYPAQ

Nucleotide

• Length: 324 bp

>AT65907 NZ_CP017087:3493208-3493531 [Enterobacter sp. HK169]
ATGCCATTCACACTATCCCATGGATGGGGGATACAAAGCGATATAACCCAACGATTTGGCGCAAGATTAGTTCAGGAAGG
CAACCGGCTGCATTACCTGGCTGACAGGGCTAGTTTGACGGGAAGCTTTAGCCCAGAGCAGCTACAAAGCCTGGAAAATG
CTTTCCCACTGTTTATAGAGCAGTTAGGAAATATGTTGCGTTCCGGTGAGCTAAATCCACAGCAGCAACGTCAGATGACC
ATTCAGCTTACAGGTCTAACTTGTATAGCTGATACTCTTAGTAGCTGGGGCTACGTTTACCTCACTGTTTATCCCGCCCA
ATAA