Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3443985..3444501 Replicon chromosome
Accession NZ_CP017087
Organism Enterobacter sp. HK169

Toxin (Protein)


Gene name relE Uniprot ID A0A7W2VUY1
Locus tag EnteroDNA1_RS16375 Protein ID WP_033144499.1
Coordinates 3444217..3444501 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag EnteroDNA1_RS16370 Protein ID WP_008501400.1
Coordinates 3443985..3444227 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EnteroDNA1_RS16355 3439986..3440726 + 741 WP_033144496.1 KDGP aldolase family protein -
EnteroDNA1_RS16360 3440841..3441977 + 1137 WP_069303565.1 lactonase family protein -
EnteroDNA1_RS16365 3441997..3443907 + 1911 WP_069303566.1 BglG family transcription antiterminator -
EnteroDNA1_RS16370 3443985..3444227 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EnteroDNA1_RS16375 3444217..3444501 + 285 WP_033144499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EnteroDNA1_RS16380 3444505..3444969 - 465 WP_048980697.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EnteroDNA1_RS16385 3445111..3447249 - 2139 WP_045888490.1 anaerobic ribonucleoside-triphosphate reductase -
EnteroDNA1_RS16390 3447626..3449269 - 1644 WP_069303567.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.3350

>T65906 WP_033144499.1 NZ_CP017087:3444217-3444501 [Enterobacter sp. HK169]
MTYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVSPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T65906 NZ_CP017087:3444217-3444501 [Enterobacter sp. HK169]
ATGACTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGCAGACTGTAAAAGACCAGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAGCCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGATCGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
CGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT65906 WP_008501400.1 NZ_CP017087:3443985-3444227 [Enterobacter sp. HK169]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT65906 NZ_CP017087:3443985-3444227 [Enterobacter sp. HK169]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2VUY1

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References