Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2144213..2144870 Replicon chromosome
Accession NZ_CP017087
Organism Enterobacter sp. HK169

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag EnteroDNA1_RS10050 Protein ID WP_021242050.1
Coordinates 2144213..2144623 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag EnteroDNA1_RS10055 Protein ID WP_010435322.1
Coordinates 2144604..2144870 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EnteroDNA1_RS10030 2140206..2141939 - 1734 WP_069303274.1 single-stranded-DNA-specific exonuclease RecJ -
EnteroDNA1_RS10035 2141945..2142658 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EnteroDNA1_RS10040 2142687..2143583 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
EnteroDNA1_RS10045 2143685..2144206 + 522 WP_023309099.1 flavodoxin FldB -
EnteroDNA1_RS10050 2144213..2144623 - 411 WP_021242050.1 protein YgfX Toxin
EnteroDNA1_RS10055 2144604..2144870 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
EnteroDNA1_RS10060 2145165..2146145 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
EnteroDNA1_RS10065 2146220..2146879 - 660 WP_023309101.1 hemolysin III family protein -
EnteroDNA1_RS10075 2147045..2147357 - 313 Protein_1984 ASCH domain-containing protein -
EnteroDNA1_RS10080 2147409..2148140 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
EnteroDNA1_RS10085 2148257..2149690 + 1434 WP_069303275.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T65904 WP_021242050.1 NZ_CP017087:c2144623-2144213 [Enterobacter sp. HK169]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T65904 NZ_CP017087:c2144623-2144213 [Enterobacter sp. HK169]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTCGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGGGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT65904 WP_010435322.1 NZ_CP017087:c2144870-2144604 [Enterobacter sp. HK169]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT65904 NZ_CP017087:c2144870-2144604 [Enterobacter sp. HK169]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References