Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1292350..1292940 Replicon chromosome
Accession NZ_CP017087
Organism Enterobacter sp. HK169

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag EnteroDNA1_RS06235 Protein ID WP_064672767.1
Coordinates 1292350..1292682 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag EnteroDNA1_RS06240 Protein ID WP_033145928.1
Coordinates 1292683..1292940 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EnteroDNA1_RS06220 1288514..1289839 + 1326 WP_069303042.1 SidA/IucD/PvdA family monooxygenase -
EnteroDNA1_RS06225 1289866..1292055 + 2190 WP_045356712.1 TonB-dependent siderophore receptor -
EnteroDNA1_RS06235 1292350..1292682 - 333 WP_064672767.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EnteroDNA1_RS06240 1292683..1292940 - 258 WP_033145928.1 antitoxin Antitoxin
EnteroDNA1_RS06245 1293232..1293621 - 390 WP_059445031.1 RidA family protein -
EnteroDNA1_RS06250 1293763..1294683 + 921 WP_069303043.1 LysR family transcriptional regulator -
EnteroDNA1_RS06255 1294759..1295061 - 303 WP_029741460.1 XRE family transcriptional regulator -
EnteroDNA1_RS06260 1295066..1295419 - 354 WP_069303044.1 type II toxin-antitoxin system RelE/ParE family toxin -
EnteroDNA1_RS06265 1295597..1296490 - 894 WP_069303045.1 LysR family transcriptional regulator -
EnteroDNA1_RS06270 1296661..1297269 + 609 WP_083239546.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11798.63 Da        Isoelectric Point: 9.4051

>T65900 WP_064672767.1 NZ_CP017087:c1292682-1292350 [Enterobacter sp. HK169]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

>T65900 NZ_CP017087:c1292682-1292350 [Enterobacter sp. HK169]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTTCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGAACAACAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAACGGCATGCGGCTGGAACGCATACCTGACGCCGTTGTAAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTGAATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT65900 WP_033145928.1 NZ_CP017087:c1292940-1292683 [Enterobacter sp. HK169]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT65900 NZ_CP017087:c1292940-1292683 [Enterobacter sp. HK169]
ATGTATACAACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAACT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAGCGGCCTCACTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGCGAAGAGGAGCGGGAATGGATCGATGCGCCTGCGGTG
GGCAGGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References