Detailed information of TA system TA065885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1869040..1869685
• Replicon: chromosome
• Accession: NZ_CP017085
• Organism: Proteus mirabilis strain T18

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: BG029_RS08920
• Protein ID: WP_004247035.1
• Coordinates: 1869500..1869685 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: BG029_RS08915
• Protein ID: WP_004247034.1
• Coordinates: 1869040..1869453 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG029_RS20300	1864593..1864751	-	159	WP_004247025.1	hypothetical protein	-
BG029_RS20305	1865203..1865379	+	177	WP_004247793.1	hypothetical protein	-
BG029_RS08885	1865550..1866296	-	747	WP_017628402.1	methyltransferase domain-containing protein	-
BG029_RS08895	1867146..1867724	+	579	WP_017628400.1	alpha/beta hydrolase	-
BG029_RS08900	1867837..1868130	-	294	Protein_1696	LysE family transporter	-
BG029_RS08910	1868444..1868944	-	501	WP_004247032.1	response regulator	-
BG029_RS08915	1869040..1869453	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BG029_RS08920	1869500..1869685	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
BG029_RS08925	1869796..1870566	+	771	Protein_1700	DUF1073 domain-containing protein	-
BG029_RS08935	1871125..1871676	-	552	WP_017628396.1	PH domain-containing protein	-
BG029_RS08940	1871740..1872054	-	315	WP_017628395.1	hypothetical protein	-
BG029_RS08950	1872461..1874194	-	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
BG029_RS08955	1874218..1874445	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1859165..1881667	22502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T65885 WP_004247035.1 NZ_CP017085:c1869685-1869500 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T65885 NZ_CP017085:c1869685-1869500 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT65885 WP_004247034.1 NZ_CP017085:c1869453-1869040 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT65885 NZ_CP017085:c1869453-1869040 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85